APHAR - Austrian Pharmacological Society - Österreichische Pharmakologische Gesellschaft

GENERAL INFORMATION ABSTRACTS TRAVEL INFORMATION HIGHLIGHTS
GART 2015 SCIENTIFIC PROGRAM SOCIAL EVENTS SPONSORS

21st Scientific Symposium of
the Austrian Pharmacological Society APHAR
Joint meeting with the British Pharmacological Society and the Pharmacological Societies of Croatia, Serbia and Slovenia
Celebrating the 20th Anniversary of APHAR
and the 25th Anniversary of EPHAR
Graz, Austria, 16–18 September 2015
SCIENTIFIC PROGRAM

← download the (preliminary) program
In the program below, abstracts with numbers starting with 'A' are published in Intrinsic Activity, 2015; 3(Suppl.2)
(abstract numbers link to the online publication).
Presentation numbers beginning with 'X' are unpublished presentations.

Download Poster PDF:
Size A4, A3, A2

WEDNESDAY – TALKS THURSDAY – TALKS FRIDAY – TALKS
WEDNESDAY – POSTERS THURSDAY – POSTERS FRIDAY – POSTERS

Oral Communications – Session 4
Chair: Harald H. Sitte (Vienna)
08:00–08:15
→ A2.3 Mechanism of low-efficacy substrate efflux at the human serotonin transporter
Shreyas Bhat, Peter S. Hasenhuetl, Walter Sandtner and Michael Freissmuth (Vienna)
08:15–08:30
→ A2.16 The impact of phosphatidylinositol-4,5-bisphosphate (PIP₂) on serotonin transport function
Tina Hofmaier, Oliver Kudlacek, Thomas Stockner, Stefan Boehm and Harald H. Sitte (Vienna)
08:30–08:45
→ A2.20 Kinetic interrogation of substrate binding and transport in the serotonin transporter
Peter S. Hasenhuetl, Klaus Schicker, Harald H. Sitte, Michael Freissmuth and Walter Sandtner (Vienna)
08:45–09:00
→ A2.1 Unnatural amino acids as a novel tool to study the folding of the serotonin transporter
Carina Kern, Ali El-Kasaby, Thomas Stockner, Michael Freissmuth and Sonja Sucic (Vienna)
09:00–09:15
→ X.1 A step towards understanding the energetics of monoamine transporters: lessons learned from a bacterial leucine transporter
Kumaresan Jayaraman, Azmat Sohail, SanthoshKannan Venkatesan, Walter Sandtner, Harald H. Sitte and Thomas Stockner (Vienna)
09:15–09:30
→ A2.15 Monitoring the movement of helix 1a of LeuT_Aa in micelles versus liposome system by using luminescence resonance energy transfer (LRET)
Azmat Sohail, Kumaresan Jayaraman, Peggy Stolt-Bergner, Gerhard F. Ecker, Michael Freissmuth, Thomas Stockner, Walter Sandtner and Harald H. Sitte (Vienna)

09:30–10:00
Coffee break / Posters

Oral Communications – Session 5
Chairs: Mojca Kržan (Ljubljana) & Stefan Böhm (Vienna)
10:00–10:15
→ A2.21 Phosphorylation of K_V7.2 regulates its PIP₂ sensitivity
Fatma A. Erdem, Isabella Salzer, Wei-Qiang Chen, Seok Heo, Helmut Kubista, Mark S. Shapiro, Gert Lubec, Stefan Boehm and Jae-Won Yang (Vienna, San Antonio)
10:15–10:30
→ X.3 Autism spectrum disorder-related Ca_V1.3 mutations alter channel function in a splice-variant-dependent manner
Alexandra Pinggera, Giulia Negro, Andreas Lieb, Bruno Benedetti, Michaela Lampert, Stefania Monteleone, Klaus R. Liedl, Petronel Tuluc and Jörg Striessnig (Innsbruck)
10:30–10:45
→ A2.17 Functional and physical interactions between P2Y receptors and ion channels
Hend Gafar, Manuel Domínguez Rodríguez, Giri K. Chandaka, Klaus Schicker and Stefan Boehm (Vienna)
10:45–11:00
→ A7.3 Deuteration changes the binding of some histaminergic agonists to the histamine H₂ receptor in astrocytes
Mojca Kržan and Janez Mavri (Ljubljana)
Plenary Lecture (Jubilee Lecture)
11:00–12:00 Norbert Bischofberger (Gilead Sciences, Foster City, CA, USA)
“Antiviral drug discovery and development: combating the global threat of HIV, HCV and Ebola virus”

12:00–13:30 Lunch break / → POSTER Session II

Oral Communications – Session 6
Chair: Josef Donnerer (Graz)
13:30–13:45
→ A5.4 Effects of titanium dioxide nanoparticles on growth of malignant melanoma cells
Bogdan Zdravković, Tanja Prunk, Mojca Lunder and Polonca Ferk (Maribor, Ljubljana)
13:45–14:00
→ A5.6 Stage-dependent interleukin-6 component in statin-induced apoptosis of metastatic melanoma cells unmasked by tocilizumab
Martin Hohenegger, Christoph Minichsdorfer, Christine Wasinger, Bihter Atil and Evelyn Sieczkowski (Vienna)
14:00–14:15
→ A5.7 Characterization of STAT5 serine phosphorylation as a drug target in BCR-ABL1⁺ leukemia
Angelika Berger, Andrea Hoelbl-Kovacic, Lukas Höfling, Gregor Hörmann, Stefan Kubicek, Richard Moriggl, Fabrice Gouilleux and Veronika Sexl (Vienna, Tours)
14:15–14:30
→ A5.8 CDK4 and CDK6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis
Florian Bellutti, Michaela Prchal-Murphy, Esther Rodríguez-Díez, Victor Quereda, Marcos Malumbres and Veronika Sexl (Vienna, Madrid)
14:30–14:45
→ X.9 The role of the atypical cannabinoid receptor GPR55 in colon carcinogenesis
Carina Hasenoehrl, David Feuersinger, Johannes Haybaeck, Rufina Schuligoi, Martin Gauster, Eva Sturm and Rudolf Schicho (Graz)

14:45–15:15
Coffee break / Posters

Oral Communications – Session 7
Chairs: Francesca Levi-Shaffer (Jerusalem) & Mauro Perretti (London)
15:15–15:30
→ X.10 LPS-induced expression of the novel inflammatory response factor strawberry notch homolog 2 co-localizes with pY-STAT3 in the central nervous system
Magdalena Grill, Taylor E. Syme, Ákos Heinemann and Iain L. Campbell (Graz, Sydney)
15:30–15:45
→ X.8 PGE₂ released by alveolar epithelial cells protects the pulmonary endothelial barrier integrity
Thomas Bärnthaler, Jovanna Marić, Viktória Kónya, Wolfgang Platzer, Ilse Lanz, Rufina Schuligoi and Ákos Heinemann (Graz)
15:45–16:00
→ X.6 Inhibition of eosinophil infiltration contributes to the improvement of TNBS colitis by the DP₂ antagonist OC000459
Balázs Radnai, Eva M. Sturm, Angela Stančić, Katharina Jandl, Magdalena Grill, Christoph Högenauer, Gregor Gorkiewicz, Ákos Heinemann and Rudolf Schicho (Graz)
Plenary Lecture
16:00–17:00 Mauro Perretti (University College, London, UK)
“Resolution Pharmacology: therapeutic innovation in inflammation”
“Speed Dating for Careers in Science”
17:00–18:00
(parallel session)
room SR07.11 The “Speed Dating for Careers in Science” is aimed at students and early career scientists. This is your chance to get to know your peers within the field, meet new collaborators and discuss what’s new and upcoming. Find out more about potential career directions, gain tips for a successful career, and meet new people who are interested and involved in the same field as you.
Refreshments will be provided for all participants.
Organised by the BPS Young Pharmacologists.
APHAR General Assembly
17:00–18:30
(parallel session) General Assembly of APHAR
(Regular members of APHAR; representatives of associate members)

APHAR & EPHAR Jubilee Dinner
19:30 Brauhaus Puntigam (Hubertussaal)
Triesterstraße 361
Celebrating 20 years of the Austrian Pharmacological Society and 25 years of the Federation of European Pharmacological Societies
Free for registered participants
Take Tram no.5 (direction Puntigam) and get off at the penultimate stop (Brauhaus Puntigam)

_________
03.08.2015

GENERAL INFORMATION	ABSTRACTS	TRAVEL INFORMATION	HIGHLIGHTS
GART 2015	SCIENTIFIC PROGRAM	SOCIAL EVENTS	SPONSORS

WEDNESDAY – TALKS	THURSDAY – TALKS	FRIDAY – TALKS
WEDNESDAY – POSTERS	THURSDAY – POSTERS	FRIDAY – POSTERS


	Oral Communications – Session 4
	Chair: Harald H. Sitte (Vienna)
08:00–08:15 → A2.3	Mechanism of low-efficacy substrate efflux at the human serotonin transporter Shreyas Bhat, Peter S. Hasenhuetl, Walter Sandtner and Michael Freissmuth (Vienna)
08:15–08:30 → A2.16	The impact of phosphatidylinositol-4,5-bisphosphate (PIP₂) on serotonin transport function Tina Hofmaier, Oliver Kudlacek, Thomas Stockner, Stefan Boehm and Harald H. Sitte (Vienna)
08:30–08:45 → A2.20	Kinetic interrogation of substrate binding and transport in the serotonin transporter Peter S. Hasenhuetl, Klaus Schicker, Harald H. Sitte, Michael Freissmuth and Walter Sandtner (Vienna)
08:45–09:00 → A2.1	Unnatural amino acids as a novel tool to study the folding of the serotonin transporter Carina Kern, Ali El-Kasaby, Thomas Stockner, Michael Freissmuth and Sonja Sucic (Vienna)
09:00–09:15 → X.1	A step towards understanding the energetics of monoamine transporters: lessons learned from a bacterial leucine transporter Kumaresan Jayaraman, Azmat Sohail, SanthoshKannan Venkatesan, Walter Sandtner, Harald H. Sitte and Thomas Stockner (Vienna)
09:15–09:30 → A2.15	Monitoring the movement of helix 1a of LeuT_Aa in micelles versus liposome system by using luminescence resonance energy transfer (LRET) Azmat Sohail, Kumaresan Jayaraman, Peggy Stolt-Bergner, Gerhard F. Ecker, Michael Freissmuth, Thomas Stockner, Walter Sandtner and Harald H. Sitte (Vienna)
09:30–10:00	Coffee break / Posters
	Oral Communications – Session 5
	Chairs: Mojca Kržan (Ljubljana) & Stefan Böhm (Vienna)
10:00–10:15 → A2.21	Phosphorylation of K_V7.2 regulates its PIP₂ sensitivity Fatma A. Erdem, Isabella Salzer, Wei-Qiang Chen, Seok Heo, Helmut Kubista, Mark S. Shapiro, Gert Lubec, Stefan Boehm and Jae-Won Yang (Vienna, San Antonio)
10:15–10:30 → X.3	Autism spectrum disorder-related Ca_V1.3 mutations alter channel function in a splice-variant-dependent manner Alexandra Pinggera, Giulia Negro, Andreas Lieb, Bruno Benedetti, Michaela Lampert, Stefania Monteleone, Klaus R. Liedl, Petronel Tuluc and Jörg Striessnig (Innsbruck)
10:30–10:45 → A2.17	Functional and physical interactions between P2Y receptors and ion channels Hend Gafar, Manuel Domínguez Rodríguez, Giri K. Chandaka, Klaus Schicker and Stefan Boehm (Vienna)
10:45–11:00 → A7.3	Deuteration changes the binding of some histaminergic agonists to the histamine H₂ receptor in astrocytes Mojca Kržan and Janez Mavri (Ljubljana)
	Plenary Lecture (Jubilee Lecture)
11:00–12:00	Norbert Bischofberger (Gilead Sciences, Foster City, CA, USA) “Antiviral drug discovery and development: combating the global threat of HIV, HCV and Ebola virus”

12:00–13:30	Lunch break / → POSTER Session II

	Oral Communications – Session 6
	Chair: Josef Donnerer (Graz)
13:30–13:45 → A5.4	Effects of titanium dioxide nanoparticles on growth of malignant melanoma cells Bogdan Zdravković, Tanja Prunk, Mojca Lunder and Polonca Ferk (Maribor, Ljubljana)
13:45–14:00 → A5.6	Stage-dependent interleukin-6 component in statin-induced apoptosis of metastatic melanoma cells unmasked by tocilizumab Martin Hohenegger, Christoph Minichsdorfer, Christine Wasinger, Bihter Atil and Evelyn Sieczkowski (Vienna)
14:00–14:15 → A5.7	Characterization of STAT5 serine phosphorylation as a drug target in BCR-ABL1⁺ leukemia Angelika Berger, Andrea Hoelbl-Kovacic, Lukas Höfling, Gregor Hörmann, Stefan Kubicek, Richard Moriggl, Fabrice Gouilleux and Veronika Sexl (Vienna, Tours)
14:15–14:30 → A5.8	CDK4 and CDK6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis Florian Bellutti, Michaela Prchal-Murphy, Esther Rodríguez-Díez, Victor Quereda, Marcos Malumbres and Veronika Sexl (Vienna, Madrid)
14:30–14:45 → X.9	The role of the atypical cannabinoid receptor GPR55 in colon carcinogenesis Carina Hasenoehrl, David Feuersinger, Johannes Haybaeck, Rufina Schuligoi, Martin Gauster, Eva Sturm and Rudolf Schicho (Graz)
14:45–15:15	Coffee break / Posters
	Oral Communications – Session 7
	Chairs: Francesca Levi-Shaffer (Jerusalem) & Mauro Perretti (London)
15:15–15:30 → X.10	LPS-induced expression of the novel inflammatory response factor strawberry notch homolog 2 co-localizes with pY-STAT3 in the central nervous system Magdalena Grill, Taylor E. Syme, Ákos Heinemann and Iain L. Campbell (Graz, Sydney)
15:30–15:45 → X.8	PGE₂ released by alveolar epithelial cells protects the pulmonary endothelial barrier integrity Thomas Bärnthaler, Jovanna Marić, Viktória Kónya, Wolfgang Platzer, Ilse Lanz, Rufina Schuligoi and Ákos Heinemann (Graz)
15:45–16:00 → X.6	Inhibition of eosinophil infiltration contributes to the improvement of TNBS colitis by the DP₂ antagonist OC000459 Balázs Radnai, Eva M. Sturm, Angela Stančić, Katharina Jandl, Magdalena Grill, Christoph Högenauer, Gregor Gorkiewicz, Ákos Heinemann and Rudolf Schicho (Graz)
	Plenary Lecture
16:00–17:00	Mauro Perretti (University College, London, UK) “Resolution Pharmacology: therapeutic innovation in inflammation”
	*“Speed Dating for Careers in Science”*
17:00–18:00 (parallel session) room SR07.11	The “Speed Dating for Careers in Science” is aimed at students and early career scientists. This is your chance to get to know your peers within the field, meet new collaborators and discuss what’s new and upcoming. Find out more about potential career directions, gain tips for a successful career, and meet new people who are interested and involved in the same field as you. Refreshments will be provided for all participants. Organised by the BPS Young Pharmacologists.
	APHAR General Assembly
17:00–18:30 (parallel session)	General Assembly of APHAR (Regular members of APHAR; representatives of associate members)

	APHAR & EPHAR Jubilee Dinner
19:30	Brauhaus Puntigam (Hubertussaal) Triesterstraße 361 Celebrating 20 years of the Austrian Pharmacological Society and 25 years of the Federation of European Pharmacological Societies Free for registered participants Take Tram no.5 (direction Puntigam) and get off at the penultimate stop (Brauhaus Puntigam)