THURSDAY 19 Nov	FRIDAY 20 Nov	SATURDAY 21 Nov	POSTERS 19−21 Nov
GENERAL INFORMATION	HIGHLIGHTS	SOCIAL PROGRAM	TRAVEL & ACCOMODATION

15th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Invited Guest Societies: Hungarian Society of Experimental and Clinical Pharmacology (MFT) and Slovenian Pharmacological Society (SDF) Graz, 19–21 November 2009 PREVIEW OF SUBMITTED ABSTRACTS Authors are requested to check abstracts for errors (see preview below). Please send corrections until 10 September. → author index Abstracts will be published in BMC Pharmacology (Click here to go back to the meeting page)

Click on icon above for print version of programme

Austrian Pharmacological Society (APHAR)
(*denotes presenting author; click on the abstract icon for the abstract preview)
A1	The targeting of US28 is dependent on GASP-1 Elisabeth Moser*, Pia Tschische, Wolfgang Platzer, Veronika Pommer, Dawn Thompson, Helmut Schaider, Lene Martini, Jennifer Whistler and Maria Waldhoer (Graz, San Francisco)
A2	Inhibitory effects of prostaglandin EP4 receptors on human eosinophils Petra Luschnig-Schratl*, Eva M. Sturm, Viktória Kónya, Rufina Schuligoi and Ákos Heinemann (Graz)
A3	GPR55: signaling pathways and functions Nariman Balenga*, Ralf Schröder, Julia Kargl, Wolfgang Platzer, Stefanie Blättermann, Ákos Heinemann, Evi Kostenis and Maria Waldhoer (Graz, Bonn)
A4	The sorting protein GASP-1 regulates the constitutive signaling capacity of the virally encoded chemokine receptor US28 Pia Tschische*, Elisabeth Moser , Dawn Thompson, Wolfgang Platzer, Henry Vischer, Martine J. Smit, Helmut Schaider, Lene Martini, Jennifer Whistler and Maria Waldhoer (Graz, San Francisco, Amsterdam)
A5	Interactions of the G protein-coupled receptor-associated sorting proteins (GASP) 1 and 2 with the novel cannabinoid receptor GPR55 Julia Kargl*, Nariman Balenga, Lene Martini, Jennifer Whistler and Maria Waldhoer (Graz, San Francisco)
A6	The effect of carbamylation on the functionality of high-density lipoprotein Michael Holzer*, Martin Gauster, Ruth Birner-Grünberger and Gunther Marsche (Graz)
A7	Advanced oxidation protein products are antagonists of the HDL receptor SR-BI Gunther Marsche*, Sasa Frank, Andelko Hrzenjak, Michael Holzer, Ákos Heinemann and Karl Öttl (Graz)
A8	Prostaglandin E2 acts via the EP4 receptor to inhibit platelet aggregation Sonia Philipose*, Martina Ofner, Ákos Heinemann and Rufina Schuligoi (Graz)
A9	Involvement of dynorphin in anxiogenic effects of estrogen Iris Kastenberger*, Eduard Schunk, Herbert Herzog and Christoph Schwarzer (Innsbruck, Sydney)
A10	Endothelial prostaglandin I2 restrains eosinophil trafficking Viktória Kónya*, Eva M. Sturm, Annarita Graziani and Ákos Heinemann (Graz)
A11	Store-operated calcium entry into rat basophil leukaemia cells: contribution of TRPC3 and Orai1 Hannes Schleifer*, Michael Poteser, Christoph Romanin and Klaus Groschner (Graz, Linz)
A12	Mutations in the amino-terminus impair amphetamine-induced efflux by inducing inward-facing conformations of the serotonin transporter Sonja Sucic*, Stephan Dallinger, Barbara Zdrazil, Oliver Kudlacek, Walter Sandtner, Gerhard F. Ecker, Michael Freissmuth and Harald H. Sitte (Vienna)
A13	The gut–mood axis: a novel role of the gut hormone peptide YY on emotional-affective behaviour in mice Evelin Painsipp*, Herbert Herzog and Peter Holzer (Graz, Sydney)
A14	Characterization of receptors involved in serotonin contractions of isolated human umbilical artery in uncomplicated pregnancy Miroslav Radenković*, Nebojša Radunović, Paja Momčilov and Leposava Grbović (Belgrade)
A15	Modification of actin fibers changes the electrical phenotype of cardiac myofibroblasts Christian Rosker*, Nicolò Salvarani and Stephan Rohr (Bern)
A16	In vitro and in vivo profiling of P-glycoprotein in human neuroblastoma and rhabdomyosarcoma cells under simvastatin exposure Evelyn Sieczkowski*, Peter Ambros and Martin Hohenegger (Vienna)
A17	Nucleotides excite sensory neurons via two P2Y receptors and a dual signaling cascade Arsalan Yousuf* and Stefan Boehm (Vienna)
A18	P2Y1 receptors are linked to KCa2 channels in PC12 cells Klaus Schicker* and Stefan Boehm (Vienna)
A19	Adult neurogenesis in a psychopathological mouse model of trait anxiety and comorbid depression-like behavior: effect of antidepressants Anupam Sah*, Stefano Gaburro, Claudia Schmuckermair, Simone B. Sartori, Markus Hauschild, Ludwig Czibere, Regina Irschick, Lars Klimaschewski, Rainer Landgraf and Nicolas Singewald (Innsbruck, Munich)
A20	L-type voltage-gated calcium channels in hippocampal neurons and their potential as anti-epilept(ogen)ic drug targets Petra Geier*, Michael Lagler, Stefan Boehm and Helmut Kubista (Vienna)
A21	CaV1.3 L-type calcium channels modulate depression-like behavior in mice independent of deaf phenotype Perrine Busquet*, Ngoc K. Nguyen, Eduard Schmid, Naoyuki Tanimoto, Mathias W. Seeliger, Tamar Ben-Yosef, Fengxia Mizuno, Abram Akopian, Nicolas Singewald and Jörg Striessnig (Vienna)
A22	3,5-Di-t-butyl catechol (DTCAT) as an activator of the human skeletal muscle ryanodine receptor Ca2+ channel and its evaluation as a test substance for the assessment of susceptibility to malignant hyperthermia Caterina Lacava, Andrea Michalek-Sauberer, Birgit Kraft, Giampietro Sgaragli, Elisabeth Sipos, Carmen Höller, Hans-Georg Kress, Fabio Fusi and Lukas G. Weigl* (Vienna, Siena)
A23	Benzodiazepines modulate GABAA receptors by reducing a gamma-subunit-mediated inhibition of GABA sensitivity Igor Baburin*, Sophia Khom, Eugen Timin, Annette Hohaus, Werner Sieghart and Steffen Hering (Vienna)
A24	From frog oocytes to mammalian cells: substantial differences in modulation of NaV1.4 channel slow kinetic behaviour by the β1 subunit Péter Lukács*, René Cervenka, Touran Zarrabi, Xaver König, Karlheinz Hilber and Hannes Todt (Vienna)
A25	Double mutant gating perturbation analysis predicts a high conformational stability of the domain IV S6 segment of the voltage-gated Na+ channel René Cervenka*, Touran Zarrabi, Péter Lukács, Xaver König, Karlheinz Hilber and Hannes Todt (Vienna)
A26	Attenuation by a novel synthetic analogue of ACTH4–7 of the learning and memory deficits in juvenile rats treated with amphetamine in utero: role of nitric oxide Valentina Bashkatova*, Sergey Sudakov, Darya Rezvanova, Helmut Prast and Anatoly Vanin (Moscow, Innsbruck)
A27	Importance of the carboxyl terminus for folding and trafficking of the serotonin transporter Ali El-Kasaby*and Oliver Kudlacek (Vienna)
A28	Cytokine signalling in human melanoma cells determines susceptability to statin-induced apoptosis Christoph Minichsdorfer*and Martin Hohenegger (Vienna)
A29	Unexpected role of STAT1 serine727 for NK cell function Eva M. Putz*, Eva Zebedin, Agnes Csiszar, Michaela Prchal, Angelika Berger, Thomas Decker, Pavel Kovarik and Veronika Sexl (Vienna)
A30	Regulation of CFTR expression and function by NOS isoforms Christina Glöckel*, Xaver König, Herwig Just and Michael Freissmuth (Vienna)
A31	Ion channel impairments in dystrophic cardiomyocytes Xaver König*, Markus Mille, Stefanie Kimbacher, René Cervenka, Péter Lukács, Hannes Todt, Reginald E. Bittner and Karlheinz Hilber (Vienna)
A32	A2A adenosine receptor interacting partners (interactome) Ingrid Gsandtner*, Simon Keuerleber, Patrick Thurner and Oliver Kudlacek (Vienna)
A33	The role of NPY in expression and extinction of conditioned fear Dilip Verma, Ramon O. Tasan*, Herbert Herzog and Günther Sperk (Innsbruck, Sydney)
A34	Protein kinase C-ζ is involved in the inhibition of eosinophil migration Eva M. Sturm*, Gerald P. Parzmair, Petra Luschnig-Schratl, Viktória Kónya and Ákos Heinemann (Graz)
A35	Bioavailability of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats and distribution in various tissues Karin Wölkart*, Reginald Frye, Hartmut Derendorf, Veronika Butterweck and Rudolf Bauer (Graz, Gainesville)
A36	Absolute and relative bioavailabilities of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after intravenous and oral single doses in rats Karin Wölkart*, Reginald Frye, Hartmut Derendorf, Veronika Butterweck and Rudolf Bauer (Graz, Gainesville)
A37	A relationship between membrane permeability of amphetamines and serotonin efflux via serotonin transporters Walter Sandtner*, Klaus Gerstbrein and Harald H. Sitte (Vienna)
A38	Active metabolites formed during hepatic first-pass: simulations featuring their contribution to the overall effect in altered liver clearance and drug-drug interactions Ahmed M. Abdelaziz*, Mohammad al-Araby, Laila Mahran, Hilde Spahn-Langguth (Cairo, Graz)
A39	Endogenous dynorphin in emotional control and stress response Christoph Schwarzer*, Walter Wittmann, Eduard Schunk, Iris Kastenberger, Stefano Gaburro, Nicolas Singewald and Herbert Herzog (Innsbruck, Sydney)
A40	Bioactivation of nitroglycerin by the East Asian variant of aldehyde dehydrogenase-2 Matteo Beretta*, Antonius C.F. Gorren, Verena M. Wenzl, Robert Weis, Michael Russwurm, Doris Koesling, Kurt Schmidt and Bernd Mayer (Graz, Bochum)
APHAR Section of Clinical Pharmacology
(*denotes presenting author; click on the abstract icon for the abstract preview) (Abstracts K1–K10 will not be published)
K1	In vitro and in vivo activity of sphingosine kinase 1 LNA oligonucleotides in gastric cancer Thorsten Füreder*, Doris Hoeflmayer, Agnes Jaeger-Lansky, Bo Hansen and Volker Wacheck (Vienna, Hørsholm)
K2	Retinal vasodilatation is maintained to exogenous nitric oxide but reduced to flicker stimulation in type 1 diabetes Leopold Schmetterer*, Berthold Pemp, Gerhard Garhöfer, Günther Weigert, Katharina Karl, Hemma Resch and Michael Wolzt (Vienna)
K3	Effects of moxaverine on ocular blood flow in patients with age-related macular degeneration, patients with primary open angle glaucoma and in healthy controls Doreen Schmidl*, Berthold Pemp, Gerhard Garhöfer, Michael Lasta and Leopold Schmetterer (Vienna)
K4	VIP/PACAP receptor regulation in a human sepsis model Angela Storka*, Bernhard Burian, Stefan Aschauer, Breanna Clive and Michael Wolzt (Vienna)
K5	A pilot study to assess the efficacy of tariquidar to inhibit cerebral P-glycoprotein in humans with (R)-[11C]verapamil and PET Martin Bauer*, Rudolf Karch, Claudia Wagner, Kurt Kletter, Markus Müller and Oliver Langer (Vienna, Seibersdorf)
K6	Blockade of the renin-angiotensin system by the angiotensin-converting enzyme inhibitor ramipril alters gene expression in skeletal muscle in healthy subjects Martin Brunner*, Wolfgang M. Schmidt, Robert Sauermann, Michael Krebs and Markus Müller (Vienna)
K7	FDG uptake is a surrogate marker for defining the optimal biological dose of the mTOR inhibitor everolimus in vivo Daniel Cejka, Claudia Kuntner, Matthias Preusser, Monika Fritzer-Szekeres, Barbara Füger, Thorsten Füreder, Thomas Wanek, Martin Zsebedics, Markus Müller, Oliver Langer and Volker Wacheck* (Vienna)
K8	Comparative bioactivity of subcutaneous heparin in critically ill patients with normal renal function Stefan Palkovits*, Ghazaleh Gouya, Stylianos Kapiotis, Christian Madl, Gottfried Locker, Alexander Stella, Michael Wolzt and Gottfried Heinz (Vienna)
K9	Proof of concept for the anti-von Willebrand factor aptamer ARC1779 in patients with acute thrombotic thrombocytopenic purpura (TTP) Bernd Jilma*, Eva-Luise Hobl, Petra Jilma, Jim Gilbert, Renta Hutabarat, Monika Gorczyca, Paul Knöbl (Vienna; Cambridge, MA)
K10	Proof of concept for the anti-von Willebrand factor aptamer ARC1779 in a patient with familial thrombotic thrombocytopenic purpura (TTP) Eva-Luise Hobl, Monika Gorczyca, Bernd Jilma*, Jim Gilbert, Renta Hutabarat, Paul Knöbl (Vienna; Cambridge, MA)
Hungarian Society for Experimental and Clinical Pharmacology (MFT)
(*denotes presenting author; click on the abstract icon for the abstract preview)
A41	A single neurotoxic dose of MDMA decreases BDNF expression in the frontoparietal cortex but not in the hippocampus Szilvia Vas*, Diána Kostyalik, Csaba Ádori, Rómeó D. Andó and György Bagdy (Budapest)
A42	Neuromorphological and functional effects of ecstasy during serotonergic damage and recovery Eszter Kirilly*, Brigitta Balogh, Eszter Molnár, Zita Kátai, Csaba Ádori and György Bagdy (Budapest)
A43	Characterization of different G protein coupling properties of CB1 and CB2 cannabinoid receptors and GPR55 receptor using BRET Pál Gyombolai*, Gábor Turu and László Hunyady (Budapest)
A44	Electrophysiological characteristics of heart ventricular papillary muscles in diabetic histidine decarboxylase knockout and wild-type mice Andrea Szebeni*, András Falus and Valéria Kecskeméti (Budapest)
A45	Analysis of sleep EEG during rebound sleep after three days REM deprivation Diána Kostyalik*, Szilvia Vas, Tamás Kitka, Zita Kátai and György Bagdy (Budapest)
A46	Regulating and regulated role of the orphanin FQ/nociceptin system Kornélia Tekes*, Mónika Hantos, Péter Szegi and György Csaba (Budapest)
A47	Behavioural sensitisation of rat dams treated with morphine pre- and postpartum Melinda Sobor*, Julia Timár, Susanna Gyarmati and Susanna Fürst (Budapest)
A48	Spinal interaction between μ and δ opioid receptors in naive and morphine-tolerant rats Pál Riba*, Kornél P Király, Tamás Friedmann, Mahmoud Al-Khrasani, Melinda Sobor and Susanna Fürst (Budapest)
A49	The electrophysiological and hemodynamical effects of pyruvate on diabetic and control rat hearts Gábor Bárdi*, Katarina Csoltkova, László Károlyi, Andrea Szebeni and Valéria Kecskeméti (Budapest)
A50	Investigation of the PtdIns(4,5)P2 dependence of plasma membrane receptor endocytosis in living cells Dániel Tóth*, László Hunyady and Péter Várnai (Budapest)
A51	Transactivation within the AT1 angiotensin receptor homodimer: the role of the conserved DRY motif Bence Szalai*, Péter Várnai and László Hunyady (Budapest)
A52	Search for novel antipsychotic drugs: dopamine forever? István Gyertyán* (Budapest)
A53	The role of P2X7 ATP receptors in the nervous system: potential implications in inflammatory and depression-like diseases Cecília Csölle*, Rómeó D. Andó, Mária Baranyi, József Haller and Beáta Sperlágh (Budapest)
A54	Role of sensory neurons on pancreatic beta cell function and on development of insulin resistance Barna Peitl*, Róbert Döbrönte, László Drimba, Réka Sári, József Németh and Zoltán Szilvássy (Debrecen)
Slovenian Pharmacological Soceity (SDF)
(*denotes presenting author; click on the abstract icon for the abstract preview)
A55	Cardioprotective effects of bilberry extract on ischemia-reperfusion-induced injury in isolated rat heart Lovro Žiberna*, Mojca Lunder, Špela Može, Andreja Vanzo and Gorazd Drevenšek (Ljubljana)
A56	Presence of bilitranslocase in the vascular system and its role in the vasodilatation activity of anthocyanins Lovro Žiberna*, Mojca Lunder, Špela Može, Gorazd Drevenšek and Sabina Passamonti (Ljubljana, Trieste)
A57	Cellular antioxidant activity of bilirubin in the human endothelial cell line EA.hy 926 is mediated by bilitranslocase Lovro Žiberna*, Federica Tramer and Sabina Passamonti (Ljubljana, Trieste)
A58	Sertraline and amitriptyline enhance histamine metabolism in guinea-pig tissues Simona Rajtar* and Tatjana Irman-Florjanc (Ljubljana)
A59	The role of nonneuronal neurotrophins in the brain Marija Čarman-Kržan* (Ljubljana)
A60	Monoamine neurotransmitters modulate NT-3 levels in astrocytes Damijana M. Jurič* (Ljubljana)
A61	Histamine–neurotrophin-3 interactions in cultured rat astrocytes Tina Mele*, Damijana M. Jurič and Marija Čarman-Kržan (Ljubljana)
A62	Cardiotoxic activity of polymeric 3-alkylpyridinium salts from the marine sponge Reniera sarai Mojca Lunder*, Lovro Žiberna, Kristina Sepčić and Gorazd Drevenšek (Ljubljana)
A63	The preventive cardiovascular effect of a combination of statin and angiotensin receptor blocker at sub-therapeutic doses in middle-aged healthy volunteers Petra Šinigoj*, Mojca Lunder, Martin Šinigoj, Gorazd Drevenšek and Mišo Šabovič (Ljubljana)
A64	Endothelin-1 increases osteoclastic bone resorption via endothelin A receptors during orthodontic tooth movement in rats Špela Sprogar*, Alja Meh, Tomaž Vaupotič, Andrej Cör, Martina Drevenšek and Gorazd Drevenšek (Ljubljana, Koper)
A65	The effect of cetirizine, an H1 receptor antagonist, on bone modeling during orthodontic tooth movement in rats Alja Meh*, Špela Sprogar, Janja Marc, Andrej Cör, Gorazd Drevenšek and Martina Drevenšek (Ljubljana)
A66	Pharmacogenetics of thiopurine therapy: from thiopurine S-methyltransferase to S-adenosylmethionine Irena Mlinarič-Raščan*, Miha Milek and Nataša Karas-Kuželički (Ljubljana)

  _________
  16.11.2008