APHAR - Austrian Pharmacological Society - Österreichische Pharmakologische Gesellschaft

General
Information THURSDAY
22 Nov FRIDAY
23 Nov SATURDAY
24 Nov POSTERS
23–25 Nov

13th Scientific Symposium
of the Austrian Pharmacological Society (APHAR)
Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT)
SUBMITTED ABSTRACTS

→ author index
Abstracts are published in
→ BMC Pharmacology, 2007; 7(Suppl.2)
PDF of
published abstracts
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Click on icon above for print version of programme.

Austrian Pharmacological Society (APHAR)
(*denotes presenting author; click on the abstract icon for the abstract preview)
A1 Neurokinin 1 Receptor Antagonism Promotes Active Stress Coping via Enhanced Septal 5-HT Transmission
Georg M. Singewald*, K. Ebner, N. Whittle, F. Ferraguti, N. Singewald (Innsbruck)
A2 Restricted Expression between Parvalbumin and Substance P Receptor NK₁ in Interneurones of the Lateral Amygdala
Hari Kishore Sreepathi*, F. Ferraguti (Innsbruck)
A3 GPR55 is a Novel Cannabinoid Receptor
Nariman Balenga*, A.J. Irving, M. Waldhoer (Graz, Dundee)
A4 The hCMV Chemokine Receptor US28 Prevents Melanoma Growth
Elisabeth Moser*, J. Shripad, P. Quan, H. Seidl, S. Frank, Z.-J. Liu, M. Fukunaga, R. McDaid, H. Kerl, M. Herlyn, H. Schaider, M. Waldhoer (Graz, Philadelphia)
A5 SAP102, a Novel Interaction Partner of the A_2A Adenosine Receptor
Ingrid Gsandtner*, N. Ferstl, M. Freissmuth, J. Zezula (Wien)
A6 Heterologous Expression of Membrane Proteins in Cardiac Myocytes
Miroslav Radenkovic*, H. Pankevych, O. Kudlacek, I. Gsandtner, K. Hilber (Wien)
A7 PI3Kδ: A Double-Edged Sword in Leukemia Formation
Eva Zebedin*, O. Simma, C. Schuster, E. Eckelhart, W. Warsch, D. Stoiber, E. Weisz, W.F. Pickl, R. Piekorz, M. Freissmuth, V. Sexl (Wien, Düsseldorf)
A8 Selective Serotonin Reuptake Inhibitors: A New Modality for the Treatment of Lymphoma/Leukaemia?
Christian Schuster*, N. Fernbach, U. Rix, G. Superti-Furga, M. Holy, M. Freissmuth, H.H. Sitte, V. Sexl (Wien)
A9 Duramycin Effects on Voltage-Gated Ion Channels: a QT-Prolongation Risk?
Eva Zebedin*, X. Koenig, M. Radenkovic, H. Pankevych, H. Todt, M. Freissmuth, K. Hilber (Wien)
A10 Anticonvulsant and Neuroprotective Actions of Endogenous Dynorphin
Christoph Schwarzer*, S. Loacker, E. Schunk, M. Sayyah, H. Herzog (Innsbruck, Sydney)
A11 C-Terminal Splicing Reveals Intramolecular Gating Modulation in Ca_V1.3 L-Type Ca²⁺ Channels
A. Singh, M. Gebhart, R. Fritsch, J.-C. Hoda, M. Sinnegger-Brauns, C. Romanin, J. Striessnig, Alexandra Koschak* (Innsbruck, Linz)
A12 Mapping the Interaction Sites of the Viral Encoded Chemokine Receptor US28 and the Sorting Protein GASP-1
Gerald Parzmair*, W. Platzer, M. Waldhoer (Graz)
A13 State-Dependent Dissociation of HERG Channel Inhibitors
D. Stork, Andreas Windisch*, E.N. Timin, A. Hohaus, M. Auer, G. Ecker, S. Hering (Wien)
A14 Experiments to Localize the Site for the Anxiogenic Action of NPY Mediated by Y₂ Receptors in the Mouse Brain
D. Stork, Ramon O. Tasan*, S. Weger, R. Heilbronn, N.K. Nguyen, N. Singewald, H. Herzog, G. Sperk (Innsbruck, Berlin, Sydney)
A15 Interaction Between the Selectivity Filter and the Fast Inactivation Machinery in the Voltage-Gated Na⁺ Channel
René Cerwenka*, T. Zarrabi, X. Koenig, E. Zebedin, K. Hilber, H. Todt (Wien)
A16 Activation of RhoB in Simvastatin-Induced Apoptosis of Differentiated Human Skeletal Muscle Cells
Timm Zörgiebel*, L. Weigl, H. Genth, M. Hohenegger (Wien, Hannover)
A17 Cell Adhesion-Dependent Trafficking and Targeting of TRPC4 Channels in Human Vascular Endothelium
Annarita Graziani*, M. Krenn, M. Poteser, K. Groschner (Graz)
A18 Sensitization of cAMP Formation in a Neuron-Like Cell Line
Edin Ibrišimović*, M. Bilban, C. Nanoff (Wien)
A19 Mapping the Binding Sites for Accessory Proteins on the A_2A Adenosine Receptor
Ivana Ostrouska*, I. Gsandtner, H. Pankevych, C. Nanoff, Oliver Kudlacek* (Wien)
A20 Differential Anti-Inflammatory Properties of Peroxisome Proliferator-Activated Receptors (PPAR) α and γ in Experimental Pancreatitis
Thomas Griesbacher*, V. Pommer, R. Schuligoi, B.A. Peskar (Graz)
Clinical Pharmacology Section of APHAR
(*denotes presenting author; click on the abstract icon for the abstract preview)
A21 Daptomycin Elimination by Continuous Venovenous Hemofiltration: In Vitro Evaluation of Factors Influencing Sieving and Membrane Adsorption
Claudia C. Wagner*, I. Steiner, M. Zeitlinger (Wien)
A22 In Vivo Dose Finding of Tariquidar Using (R)-[¹¹C]Verapamil μPET
Oliver Langer*, J. Bankstahl, C. Kuntner, A. Abrahim, R. Karch, J. Stanek, T. Wanek, M. Zsebedics, K. Kletter, W. Löscher, M. Müller, H. Kvaternik (Seibersdorf, Wien, Hannover)
A23 Metabolism of (R)-[¹¹C]Verapamil in Epilepsy Patients
Aiman Abrahim*, G. Luurtsema, M. Bauer, R. Karch, C. Baumgartner, K. Kletter, M. Müller, O. Langer (Wien, Seibersdorf, Amsterdam)
A24 P-Glycoprotein inhibition at the Blood-Brain Barrier Visualized with (R)-[¹¹C]Verapamil μPET
C. Kuntner, J. Bankstahl, A. Abrahim, R. Karch, J. Stanek, T. Wanek, M. Zsebedics, K. Kletter, W. Löscher, H. Kvaternik, M. Müller, Oliver Langer* (Seibersdorf, Wien, Hannover)
A25 mTORC1 Inhibition with Rapamycin or LY294002 Alone but Not in Combination Leads to AKT Phosphorylation via mTORC2 in Melanoma Cells
Johannes Werzowa*, D. Cejka, B. Dekrout, T. Fuereder, C. Thallinger, H. Pehamberger, V. Wacheck, B. Pratscher (Wien)
A26 Monitoring Platelet Activation with Two Different Shear-Dependent Function Tests: Application of PFA-100 and the Impact-R ARA
Ghazaleh Gouya*, M. Wolzt, M. Niel, B. Jilma, S. Panzer (Wien)
A27 Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise
Günther Weigert*, H. Resch, G. Garhöfer, G. Fuchsjäger-Mayrl, L. Schmetterer (Wien)
A28 Pharmacokinetics of Amphotericin B Colloidal Dispersion in Liver Failure
Stefan Weiler*, S. Weiler, R. Bellmann-Weiler, M. Joannidis, R. Bellmann (Innsbruck)
A29 Pharmacokinetics and Pharmacodynamics of the Dual FII/FX Inhibitor BIBT 986 in Endotoxin-Induced Coagulation
Judith M. Leitner*, B. Jilma, F.B. Mayr, F. Cardona, A.O. Spiel, C. Firbas, K. Rathgen, H. Stähle, U. Schühly, E.U. Graefe-Mody (Wien, Biberach)
A30 Effects of High Dose Prednisolone on Optic Nerve Head Blood Flow in Patients with Acute Optic Neuritis
Hemma Resch*, G. Weigert, G. Garhöfer, G.T. Dorner, A. Reintner, L. Schmetterer (Wien)
A31 Influence of the Duffy Genotype on Pharmacokinetics and Pharmacodynamics of Recombinant Monocyte Chemoattractant Protein (MCP-1) In Vivo
F.B. Mayr, A.O. Spiel, J.M. Leitner, C. Firbas, J. Schnee, J. Hilbert, Bernd Jilma* (Wien, Ridgefield)
Hungarian Society for Experimental and Clinical Pharmacology (MFT)
(*denotes presenting author; click on the abstract icon for the abstract preview)
A32 The Selective Enhancer Substance (–)-BPAP Counteracts the Histological and Functional Consequences of an Experimental Stroke in Rats
László Dénes*, I. Miklya (Budapest)
A33 The Basic Difference in the Pharmacological Spectrum between Methamphetamine and Its Derivative, the Enhancer Substance (–)-Deprenyl
Ildikó Miklya* (Budapest)
A34 New Method for Detecting ATP Release from Rat Hippocampal Slices
Attila Heinrich*, E.S. Vizi, B. Sperlágh (Budapest)
A35 P2 Receptor-Mediated Modulation of Noradrenaline Release by Electrical Field Stimulation and Ischemic Conditions in Superfused Rat Hippocampus Slices
Cecília Csölle*, A. Heinrich, B. Sperlágh (Budapest)
A36 Further Evidence for the Involvement of 5-HT_2C Receptors in the Pentylenetetrazole Model of Epilepsy
Pál Riba*, Gy. Bagdy, V. Kecskemáti (Budapest)
A37 Ionotropic Neurotransmitter Receptors: Activation and Allosteric Modulation
Gábor Maksay*, L. Fodor (Budapest)
A38 Evidence Against a Separate High Affinity Binding Site on the P2X₃ Receptor
Róbert Károly*, Á. Mike, Z. Gerevich, P. Illes, E.S. Vizi (Budapest)
A39 Changes in the Action of Morphine Challenge Following Perinatal Morphine Exposure in Rats
Melinda Sobor*, J. Timár, S. Gyarmati, S. Fürst (Budapest)
A40 Electrophysiological Effects of Heat Shock Proteins and Dofetilide on Cardiac Preparations of Streptozotocin-Induced Diabetic Rats
Éva Virágh*, A. Szebeni, V. Kecskeméti (Budapest)
A41 Exploring the Heterogeneity of Use-Dependent Sodium Channel Inhibitor Drugs. I: Fast- vs. Slow-Inactivated State Preference
Nóra Lenkey*, R. Károly, E.S. Vizi, Á. Mike (Budapest)
A42 Exploring the Heterogeneity of Use-Dependent Sodium Channel Inhibitor Drugs. II: Drugs Described by the Modulated Receptor Hypothesis (MRH) and/or the Guarded Receptor Hypothesis (GRH)
Árpád Mike*, N. Lenkey, R. Károly, E.S. Vizi (Budapest)
A43 Electrophysiological Characteristics of Heart Ventricular Papillary Muscles from Histidine Decarboxylase Knockout and Wild-Type Mice: Effects of Rosiglitazone
Andrea Szebeni*, V. Kecskeméti (Budapest)
A44 Potential Role of Nociceptin and Nocistatin in Central Regulation of Gastric Mucosal Defense
Zoltán S. Zádori*, N. Shujaa, K. Tekes, K. Gyires (Budapest)
A45 14-Methoxy-Metopon: a Highly Potent μ Opioid Agonist on Rat Vas Deferens
Kornél P. Király*, P. Riba, T. Friedmann, M. Al-Khrasani, H. Schmidhammer, S. Fürst (Budapest, Innsbruck)
A46 Changes in Stereotyped Behaviour Following Acute or Repeated Methylenedioxy-Methamphetamine (MDMA) Treatment
Zsuzsanna Szelényi*, Á. Bajnogel-Orosz, J. Timár, S. Gyarmati, M. Sobor, S. Fürst (Budapest)
A47 The Role of Cannabinoid CB₁ Receptor Agonists in Gastric Mucosal Protection in Rats and Mice
Nashwan Shujaa*, Z.S. Zádori, M. Al-Khrasani, S. Fürst, T. Wenger, K. Gyires (Budapest)
A48 The Possible Link between Insulin Resistance and Increased Cardiovascular Mortality
Barna Peitl*, L.P. Drimba, R. Döbrönte, J. Németh, R.Zs. Sári, Cs. Pankucsi, A. Varga, L. Fésüs, J. Tőzsér, Z. Szilvássy (Debrecen, Győr)
A49 Nitrate Tolerance-Induced Deterioration of the Ischemic Adaptability of the Heart
Zoltán Szilvássy*, J. Szaszkó, R. Döbrönte, J. Németh, R.Zs. Sári, Cs. Pankucsi, A. Varga, J. Tőzsér, L. Fésüs, B. Peitl (Debrecen, Győr)
A50 The Peripheral Antinociceptive Effect of DAMGO and 6β-Glycine-Substituted 14-O-Methyloxymorphone (HS-731) after Systemic Administration in a Mouse Visceral Pain Model
Mahmoud Al-Khrasani*, M. Spetea, T. Friedmann, P. Riba, K. Király, H. Schmidhammer, S. Fürst (Budapest, Innsbruck)
A51 Ion Channels Alteration in Dilated Cardiomyopathy in Human Heart
Viktoria Szűts*, I. Baczkó, D. Ménesi, Z. Varga-Orvos, J.Zs. Kelemen, L.G. Puskás, Z. Bódi, L. Csincsik, N. Houshmand, M. Bitay, M. Csanády, J. Norbert, L. Virág, J.Gy. Papp, A. Varró (Szeged)
Austrian Society for Toxicology (ASTOX)
(*denotes presenting author; click on the abstract icon for the abstract preview)
A52 Spin Trapping Experiments with Ethyl-Substituted EMPO Derivatives (EEMPO)
Klaus Stolze*, N. Rohr-Udilova, T. Rosenau, A. Hofinger, H. Nohl (Wien)
A53 In Situ Monitoring of the Genotoxic Effects in the Vicinity of a Petrochemical Plant with the Tradescantia Micronucleus (Trad-MCN) and with Pollen Abortion Test
Miroslav Mišík*, K. Mičieta, M. Solenská, N. Markusková, K. Mišíková, S. Knasmüller (Wien, Bratislava)
A54 H₂O₂ Detection with 10-Acetyl-3,7-Dihydroxyphenoxazine: Comparison with Homovanillic Acid
Katrin Staniek* (Wien)
A55 Toxicological Investigation of Nanoparticles: Effects on Human Cells
Letizia Farmer*, A. Graff, S. Szameit, E. Valic, H. Tuschl (Seibersdorf, Leoben, Wien)
A56 Submitochondrial Particles from Saccharomyces cerevisiae to Screen Compounds for Antiprotozoal Activity
Carmen Streicher*, G. Wiesenberger, T. Rosenau, L. Gille (Wien)
A57 Role of Fibroblast Growth Factors in Hepatocarcinogenesis of Humans and Rats
Christine Gauglhofer*, S. Sagmeister, W. Parzefall, R. Schulte-Hermann, B. Grasl-Kraupp (Wien)
A58 Role of Mesenchymal Liver Cells in Mediating Hepatic Toxicity and Carcinogenesis
Sandra Sagmeister*, W. Parzefall, C. Gauglhofer, C. Gerner, R. Schulte-Hermann, B. Grasl-Kraupp (Wien)
A59 New Epithelial and Mesenchymal Cell Lines from Primary Liver Cancer to Study Cell Interactions in Hepatocarcinogenesis
Sandra Sagmeister*, M. Eisenbauer, C. Pirker, K. Holzmann, W. Parzefall, C. Gerner, R. Schulte-Hermann, B. Grasl-Kraupp (Wien)
A60 Investigation of Genotoxic Effects of Inhalative Occupational Exposure to Vanadium: Results of a Multiple Endpoint Study
Veronika Ehrlich*, A. Nersesyan, C. Hoelzl, F. Ferk, J. Bichler, K. Atefie, E. Valic, A. Schaffer, R. Schulte-Hermann, S. Knasmüller (Wien)
A61 Influence of an Ironman Triathlon on Sister Chromatid Exchanges and High Frequency Cells
Stefanie Reichhold*, M. Meisel, O. Neubauer, K.-H. Wagner (Wien)
A62 β-Sitosterol Oxidation Products Failed to Show Mutagenic Potential in the Ames Test
Karin Koschutnig*, S. Kemmo, A.-M. Lampi, V. Piironen, K.-H. Wagner (Wien, Helsinki)
A63 Control of Hepatocellular Apoptosis by Cytokines (TGF-β1), Liver Tumor Promoter (Phenobarbital) and Nutritional Factors (Glucose): Approach to Validate the Hepatoma Cell Line HCC-1.2 as Cell Culture Model
Anneliese Karwan*, A. Karwan, J. Dornetshuber, R. Schulte-Hermann, W. Bursch (Wien)
A64 Cancer and Nutrition: Role of Amino Acids (AA) for the Regulation of Hepatocellular Apoptosis
Miriam Mayer*, A. Ellinger, A. Karwan, R. Schulte-Hermann, W. Bursch (Wien)
A65 Impact of Stereochemistry on Biological Effects of Permethrin: Induction of Apoptosis in Human Hepatoma Cells (HCC-1.2) and Primary Rat Hepatocyte Cultures
Julia Dornetshuber*, W. Bicker, M. Lämmerhofer, W. Lindner, A. Karwan, W. Bursch (Wien)
A66 Influence of Dissolved Organic Matter on the Bioavailability of Hydrophobic Organic Pollutants in Sediments Investigated by Bioassays
Klaus Wruss*, D. Todorovic, A.P. Loibner (Tulln)
A67 Lipid Hydroperoxide, an Intermediate Product of Oxidative Stress, Induces Tumour Progression-Associated Genes in Hepatocarcinoma Cells
Nataliya Rohr-Udilova*, K. Stolze, B. Grasl-Kraupp, R. Schulte-Hermann, R. Peck-Radosavljevic (Wien)
A68 iNOS Expression and Levels of Nitric Oxide in a Hepatocarcinogenesis Model of p47-NADPH Knockout Mice
Constanze Freiler*, E. Kainzbauer, R. Schulte-Hermann, W. Parzefall (Wien)

_________
15.11.2007

Austrian Pharmacological Society (APHAR)
(denotes presenting author; click on the abstract icon for the abstract preview)*
A1	Neurokinin 1 Receptor Antagonism Promotes Active Stress Coping via Enhanced Septal 5-HT Transmission Georg M. Singewald*, K. Ebner, N. Whittle, F. Ferraguti, N. Singewald (Innsbruck)
A2	Restricted Expression between Parvalbumin and Substance P Receptor NK₁ in Interneurones of the Lateral Amygdala Hari Kishore Sreepathi*, F. Ferraguti (Innsbruck)
A3	GPR55 is a Novel Cannabinoid Receptor Nariman Balenga*, A.J. Irving, M. Waldhoer (Graz, Dundee)
A4	The hCMV Chemokine Receptor US28 Prevents Melanoma Growth Elisabeth Moser*, J. Shripad, P. Quan, H. Seidl, S. Frank, Z.-J. Liu, M. Fukunaga, R. McDaid, H. Kerl, M. Herlyn, H. Schaider, M. Waldhoer (Graz, Philadelphia)
A5	SAP102, a Novel Interaction Partner of the A_2A Adenosine Receptor Ingrid Gsandtner*, N. Ferstl, M. Freissmuth, J. Zezula (Wien)
A6	Heterologous Expression of Membrane Proteins in Cardiac Myocytes Miroslav Radenkovic*, H. Pankevych, O. Kudlacek, I. Gsandtner, K. Hilber (Wien)
A7	PI3Kδ: A Double-Edged Sword in Leukemia Formation Eva Zebedin*, O. Simma, C. Schuster, E. Eckelhart, W. Warsch, D. Stoiber, E. Weisz, W.F. Pickl, R. Piekorz, M. Freissmuth, V. Sexl (Wien, Düsseldorf)
A8	Selective Serotonin Reuptake Inhibitors: A New Modality for the Treatment of Lymphoma/Leukaemia? Christian Schuster*, N. Fernbach, U. Rix, G. Superti-Furga, M. Holy, M. Freissmuth, H.H. Sitte, V. Sexl (Wien)
A9	Duramycin Effects on Voltage-Gated Ion Channels: a QT-Prolongation Risk? Eva Zebedin*, X. Koenig, M. Radenkovic, H. Pankevych, H. Todt, M. Freissmuth, K. Hilber (Wien)
A10	Anticonvulsant and Neuroprotective Actions of Endogenous Dynorphin Christoph Schwarzer*, S. Loacker, E. Schunk, M. Sayyah, H. Herzog (Innsbruck, Sydney)
A11	C-Terminal Splicing Reveals Intramolecular Gating Modulation in Ca_V1.3 L-Type Ca²⁺ Channels A. Singh, M. Gebhart, R. Fritsch, J.-C. Hoda, M. Sinnegger-Brauns, C. Romanin, J. Striessnig, Alexandra Koschak* (Innsbruck, Linz)
A12	Mapping the Interaction Sites of the Viral Encoded Chemokine Receptor US28 and the Sorting Protein GASP-1 Gerald Parzmair*, W. Platzer, M. Waldhoer (Graz)
A13	State-Dependent Dissociation of HERG Channel Inhibitors D. Stork, Andreas Windisch*, E.N. Timin, A. Hohaus, M. Auer, G. Ecker, S. Hering (Wien)
A14	Experiments to Localize the Site for the Anxiogenic Action of NPY Mediated by Y₂ Receptors in the Mouse Brain D. Stork, Ramon O. Tasan*, S. Weger, R. Heilbronn, N.K. Nguyen, N. Singewald, H. Herzog, G. Sperk (Innsbruck, Berlin, Sydney)
A15	Interaction Between the Selectivity Filter and the Fast Inactivation Machinery in the Voltage-Gated Na⁺ Channel René Cerwenka*, T. Zarrabi, X. Koenig, E. Zebedin, K. Hilber, H. Todt (Wien)
A16	Activation of RhoB in Simvastatin-Induced Apoptosis of Differentiated Human Skeletal Muscle Cells Timm Zörgiebel*, L. Weigl, H. Genth, M. Hohenegger (Wien, Hannover)
A17	Cell Adhesion-Dependent Trafficking and Targeting of TRPC4 Channels in Human Vascular Endothelium Annarita Graziani*, M. Krenn, M. Poteser, K. Groschner (Graz)
A18	Sensitization of cAMP Formation in a Neuron-Like Cell Line Edin Ibrišimović*, M. Bilban, C. Nanoff (Wien)
A19	Mapping the Binding Sites for Accessory Proteins on the A_2A Adenosine Receptor Ivana Ostrouska, I. Gsandtner, H. Pankevych, C. Nanoff, Oliver Kudlacek (Wien)
A20	Differential Anti-Inflammatory Properties of Peroxisome Proliferator-Activated Receptors (PPAR) α and γ in Experimental Pancreatitis Thomas Griesbacher*, V. Pommer, R. Schuligoi, B.A. Peskar (Graz)
Clinical Pharmacology Section of APHAR
(denotes presenting author; click on the abstract icon for the abstract preview)*
A21	Daptomycin Elimination by Continuous Venovenous Hemofiltration: In Vitro Evaluation of Factors Influencing Sieving and Membrane Adsorption Claudia C. Wagner*, I. Steiner, M. Zeitlinger (Wien)
A22	In Vivo Dose Finding of Tariquidar Using (R)-[¹¹C]Verapamil μPET Oliver Langer*, J. Bankstahl, C. Kuntner, A. Abrahim, R. Karch, J. Stanek, T. Wanek, M. Zsebedics, K. Kletter, W. Löscher, M. Müller, H. Kvaternik (Seibersdorf, Wien, Hannover)
A23	Metabolism of (R)-[¹¹C]Verapamil in Epilepsy Patients Aiman Abrahim*, G. Luurtsema, M. Bauer, R. Karch, C. Baumgartner, K. Kletter, M. Müller, O. Langer (Wien, Seibersdorf, Amsterdam)
A24	P-Glycoprotein inhibition at the Blood-Brain Barrier Visualized with (R)-[¹¹C]Verapamil μPET C. Kuntner, J. Bankstahl, A. Abrahim, R. Karch, J. Stanek, T. Wanek, M. Zsebedics, K. Kletter, W. Löscher, H. Kvaternik, M. Müller, Oliver Langer* (Seibersdorf, Wien, Hannover)
A25	mTORC1 Inhibition with Rapamycin or LY294002 Alone but Not in Combination Leads to AKT Phosphorylation via mTORC2 in Melanoma Cells Johannes Werzowa*, D. Cejka, B. Dekrout, T. Fuereder, C. Thallinger, H. Pehamberger, V. Wacheck, B. Pratscher (Wien)
A26	Monitoring Platelet Activation with Two Different Shear-Dependent Function Tests: Application of PFA-100 and the Impact-R ARA Ghazaleh Gouya*, M. Wolzt, M. Niel, B. Jilma, S. Panzer (Wien)
A27	Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise Günther Weigert*, H. Resch, G. Garhöfer, G. Fuchsjäger-Mayrl, L. Schmetterer (Wien)
A28	Pharmacokinetics of Amphotericin B Colloidal Dispersion in Liver Failure Stefan Weiler*, S. Weiler, R. Bellmann-Weiler, M. Joannidis, R. Bellmann (Innsbruck)
A29	Pharmacokinetics and Pharmacodynamics of the Dual FII/FX Inhibitor BIBT 986 in Endotoxin-Induced Coagulation Judith M. Leitner*, B. Jilma, F.B. Mayr, F. Cardona, A.O. Spiel, C. Firbas, K. Rathgen, H. Stähle, U. Schühly, E.U. Graefe-Mody (Wien, Biberach)
A30	Effects of High Dose Prednisolone on Optic Nerve Head Blood Flow in Patients with Acute Optic Neuritis Hemma Resch*, G. Weigert, G. Garhöfer, G.T. Dorner, A. Reintner, L. Schmetterer (Wien)
A31	Influence of the Duffy Genotype on Pharmacokinetics and Pharmacodynamics of Recombinant Monocyte Chemoattractant Protein (MCP-1) In Vivo F.B. Mayr, A.O. Spiel, J.M. Leitner, C. Firbas, J. Schnee, J. Hilbert, Bernd Jilma* (Wien, Ridgefield)
Hungarian Society for Experimental and Clinical Pharmacology (MFT)
(denotes presenting author; click on the abstract icon for the abstract preview)*
A32	The Selective Enhancer Substance (–)-BPAP Counteracts the Histological and Functional Consequences of an Experimental Stroke in Rats László Dénes*, I. Miklya (Budapest)
A33	The Basic Difference in the Pharmacological Spectrum between Methamphetamine and Its Derivative, the Enhancer Substance (–)-Deprenyl Ildikó Miklya* (Budapest)
A34	New Method for Detecting ATP Release from Rat Hippocampal Slices Attila Heinrich*, E.S. Vizi, B. Sperlágh (Budapest)
A35	P2 Receptor-Mediated Modulation of Noradrenaline Release by Electrical Field Stimulation and Ischemic Conditions in Superfused Rat Hippocampus Slices Cecília Csölle*, A. Heinrich, B. Sperlágh (Budapest)
A36	Further Evidence for the Involvement of 5-HT_2C Receptors in the Pentylenetetrazole Model of Epilepsy Pál Riba*, Gy. Bagdy, V. Kecskemáti (Budapest)
A37	Ionotropic Neurotransmitter Receptors: Activation and Allosteric Modulation Gábor Maksay*, L. Fodor (Budapest)
A38	Evidence Against a Separate High Affinity Binding Site on the P2X₃ Receptor Róbert Károly*, Á. Mike, Z. Gerevich, P. Illes, E.S. Vizi (Budapest)
A39	Changes in the Action of Morphine Challenge Following Perinatal Morphine Exposure in Rats Melinda Sobor*, J. Timár, S. Gyarmati, S. Fürst (Budapest)
A40	Electrophysiological Effects of Heat Shock Proteins and Dofetilide on Cardiac Preparations of Streptozotocin-Induced Diabetic Rats Éva Virágh*, A. Szebeni, V. Kecskeméti (Budapest)
A41	Exploring the Heterogeneity of Use-Dependent Sodium Channel Inhibitor Drugs. I: Fast- vs. Slow-Inactivated State Preference Nóra Lenkey*, R. Károly, E.S. Vizi, Á. Mike (Budapest)
A42	Exploring the Heterogeneity of Use-Dependent Sodium Channel Inhibitor Drugs. II: Drugs Described by the Modulated Receptor Hypothesis (MRH) and/or the Guarded Receptor Hypothesis (GRH) Árpád Mike*, N. Lenkey, R. Károly, E.S. Vizi (Budapest)
A43	Electrophysiological Characteristics of Heart Ventricular Papillary Muscles from Histidine Decarboxylase Knockout and Wild-Type Mice: Effects of Rosiglitazone Andrea Szebeni*, V. Kecskeméti (Budapest)
A44	Potential Role of Nociceptin and Nocistatin in Central Regulation of Gastric Mucosal Defense Zoltán S. Zádori*, N. Shujaa, K. Tekes, K. Gyires (Budapest)
A45	14-Methoxy-Metopon: a Highly Potent μ Opioid Agonist on Rat Vas Deferens Kornél P. Király*, P. Riba, T. Friedmann, M. Al-Khrasani, H. Schmidhammer, S. Fürst (Budapest, Innsbruck)
A46	Changes in Stereotyped Behaviour Following Acute or Repeated Methylenedioxy-Methamphetamine (MDMA) Treatment Zsuzsanna Szelényi*, Á. Bajnogel-Orosz, J. Timár, S. Gyarmati, M. Sobor, S. Fürst (Budapest)
A47	The Role of Cannabinoid CB₁ Receptor Agonists in Gastric Mucosal Protection in Rats and Mice Nashwan Shujaa*, Z.S. Zádori, M. Al-Khrasani, S. Fürst, T. Wenger, K. Gyires (Budapest)
A48	The Possible Link between Insulin Resistance and Increased Cardiovascular Mortality Barna Peitl*, L.P. Drimba, R. Döbrönte, J. Németh, R.Zs. Sári, Cs. Pankucsi, A. Varga, L. Fésüs, J. Tőzsér, Z. Szilvássy (Debrecen, Győr)
A49	Nitrate Tolerance-Induced Deterioration of the Ischemic Adaptability of the Heart Zoltán Szilvássy*, J. Szaszkó, R. Döbrönte, J. Németh, R.Zs. Sári, Cs. Pankucsi, A. Varga, J. Tőzsér, L. Fésüs, B. Peitl (Debrecen, Győr)
A50	The Peripheral Antinociceptive Effect of DAMGO and 6β-Glycine-Substituted 14-O-Methyloxymorphone (HS-731) after Systemic Administration in a Mouse Visceral Pain Model Mahmoud Al-Khrasani*, M. Spetea, T. Friedmann, P. Riba, K. Király, H. Schmidhammer, S. Fürst (Budapest, Innsbruck)
A51	Ion Channels Alteration in Dilated Cardiomyopathy in Human Heart Viktoria Szűts*, I. Baczkó, D. Ménesi, Z. Varga-Orvos, J.Zs. Kelemen, L.G. Puskás, Z. Bódi, L. Csincsik, N. Houshmand, M. Bitay, M. Csanády, J. Norbert, L. Virág, J.Gy. Papp, A. Varró (Szeged)
Austrian Society for Toxicology (ASTOX)
(denotes presenting author; click on the abstract icon for the abstract preview)*
A52	Spin Trapping Experiments with Ethyl-Substituted EMPO Derivatives (EEMPO) Klaus Stolze*, N. Rohr-Udilova, T. Rosenau, A. Hofinger, H. Nohl (Wien)
A53	*In Situ Monitoring of the Genotoxic Effects in the Vicinity of a Petrochemical Plant with the Tradescantia* Micronucleus (Trad-MCN) and with Pollen Abortion Test** Miroslav Mišík*, K. Mičieta, M. Solenská, N. Markusková, K. Mišíková, S. Knasmüller (Wien, Bratislava)
A54	H₂O₂ Detection with 10-Acetyl-3,7-Dihydroxyphenoxazine: Comparison with Homovanillic Acid Katrin Staniek* (Wien)
A55	Toxicological Investigation of Nanoparticles: Effects on Human Cells Letizia Farmer*, A. Graff, S. Szameit, E. Valic, H. Tuschl (Seibersdorf, Leoben, Wien)
A56	*Submitochondrial Particles from Saccharomyces cerevisiae* to Screen Compounds for Antiprotozoal Activity** Carmen Streicher*, G. Wiesenberger, T. Rosenau, L. Gille (Wien)
A57	Role of Fibroblast Growth Factors in Hepatocarcinogenesis of Humans and Rats Christine Gauglhofer*, S. Sagmeister, W. Parzefall, R. Schulte-Hermann, B. Grasl-Kraupp (Wien)
A58	Role of Mesenchymal Liver Cells in Mediating Hepatic Toxicity and Carcinogenesis Sandra Sagmeister*, W. Parzefall, C. Gauglhofer, C. Gerner, R. Schulte-Hermann, B. Grasl-Kraupp (Wien)
A59	New Epithelial and Mesenchymal Cell Lines from Primary Liver Cancer to Study Cell Interactions in Hepatocarcinogenesis Sandra Sagmeister*, M. Eisenbauer, C. Pirker, K. Holzmann, W. Parzefall, C. Gerner, R. Schulte-Hermann, B. Grasl-Kraupp (Wien)
A60	Investigation of Genotoxic Effects of Inhalative Occupational Exposure to Vanadium: Results of a Multiple Endpoint Study Veronika Ehrlich*, A. Nersesyan, C. Hoelzl, F. Ferk, J. Bichler, K. Atefie, E. Valic, A. Schaffer, R. Schulte-Hermann, S. Knasmüller (Wien)
A61	Influence of an Ironman Triathlon on Sister Chromatid Exchanges and High Frequency Cells Stefanie Reichhold*, M. Meisel, O. Neubauer, K.-H. Wagner (Wien)
A62	β-Sitosterol Oxidation Products Failed to Show Mutagenic Potential in the Ames Test Karin Koschutnig*, S. Kemmo, A.-M. Lampi, V. Piironen, K.-H. Wagner (Wien, Helsinki)
A63	Control of Hepatocellular Apoptosis by Cytokines (TGF-β1), Liver Tumor Promoter (Phenobarbital) and Nutritional Factors (Glucose): Approach to Validate the Hepatoma Cell Line HCC-1.2 as Cell Culture Model Anneliese Karwan*, A. Karwan, J. Dornetshuber, R. Schulte-Hermann, W. Bursch (Wien)
A64	Cancer and Nutrition: Role of Amino Acids (AA) for the Regulation of Hepatocellular Apoptosis Miriam Mayer*, A. Ellinger, A. Karwan, R. Schulte-Hermann, W. Bursch (Wien)
A65	Impact of Stereochemistry on Biological Effects of Permethrin: Induction of Apoptosis in Human Hepatoma Cells (HCC-1.2) and Primary Rat Hepatocyte Cultures Julia Dornetshuber*, W. Bicker, M. Lämmerhofer, W. Lindner, A. Karwan, W. Bursch (Wien)
A66	Influence of Dissolved Organic Matter on the Bioavailability of Hydrophobic Organic Pollutants in Sediments Investigated by Bioassays Klaus Wruss*, D. Todorovic, A.P. Loibner (Tulln)
A67	Lipid Hydroperoxide, an Intermediate Product of Oxidative Stress, Induces Tumour Progression-Associated Genes in Hepatocarcinoma Cells Nataliya Rohr-Udilova*, K. Stolze, B. Grasl-Kraupp, R. Schulte-Hermann, R. Peck-Radosavljevic (Wien)
A68	iNOS Expression and Levels of Nitric Oxide in a Hepatocarcinogenesis Model of p47-NADPH Knockout Mice Constanze Freiler*, E. Kainzbauer, R. Schulte-Hermann, W. Parzefall (Wien)