APHAR - Austrian Pharmacological Society - Österreichische Pharmakologische Gesellschaft

GENERAL INFORMATION FRIDAY 26 Nov SATURDAY 27 Nov POSTERS 26−27 Nov

16th Scientific Symposium of the
Austrian Pharmacological Society (APHAR)
Vienna, 26–27 November 2010
FRIDAY 26 NOV
• 10 Short Communcations
• 2 Plenary Lectures
• 2 Structured Poster Sessions
• Member Assembly Section Clinical Pharmacology
• General Assembly of APHAR
• APHAR Heuriger

Click on icon above for print version of programme

SHORT COMMUNICATIONS
08:30–10:00 6 Short Communications
Chair: Markus ZEITLINGER, Anna BUCSICS (Vienna)
08:30–08:45
A1 The trafficking of GPR55 is regulated by the G protein-coupled receptor-associated sorting protein 1
Julia Kargl*, Nariman Balenga, Wolfgang Platzer, Lene Martini, Jennifer Whistler and Maria Waldhoer (Graz, San Francisco)
08:45–09:00
A5 Enhanced fear expression in a psychphathological mouse model of trait anxiety: pharmacological interventions
Markus Hauschild*, Simone B. Sartori, Mirjam Bunck, Stefano Gaburro, Rainer Landgraf and Nicolas Singewald (Innsbruck, München, Martinsried)
09:00–09:15
A42 Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo
Johannes Werzowa*, Stefan Koehrer, Sabine Strommer, Daniel Cejka, Thorsten Füreder and Wacheck (Vienna)
09:15–09:30
A43 Thrombus formation is not pH-dependent
Stefan Weisshaar*, Ghazaleh Gouya and Michael Wolzt (Vienna)
09:30–09:45
A9 Is thymoquinone an antioxidant?
Katrin Staniek* and Lars Gille (Vienna)
09:45–10:00
A44 Inhibition of tissue factor pathway inhibitor (TFPI) by ARC19499 improves clotting of hemophiliac blood
Monika E. Gorczyca*, Bernd Jilma, Christoph Male, Sylvia Reitter, James C. Gilbert and Ingrid Pabinger (Vienna; Cambridge, MA)

COFFEE BREAK
10:00–10:15 Coffee Break

STRUCTURED POSTER SESSION 1
10:15–11:00 Chairs: Dagmar STOIBER-SAKAGUCHI, Jürgen ZEZULA (Vienna)
Posters A4, A6, A8, A35, A36, A39, A40, A41
(5 min per poster)

PLENARY LECTURE
11:00–12:00 Chair: Brigitte BLÖCHL-DAUM (Vienna)
John WARREN
Medical Assessor at UK Medicines Healthcare Products Regulatory Agency (MHRA) and Member of EU Scientific Advice Working Party at the European Medicines Agency (EMA)
"Drug Discovery: Lessons from Evolution"

LUNCH BREAK & FREE POSTER SESSION
12:00–14:00 Lunch Break & Free Poser Session
12:00 Mitgliederversammlung der Sektion Klinische Pharmakologie
(nur für Mitglieder der Sektion)
SHORT COMMUNICATIONS
14:00–15:00 4 Short Communications
Chairs: Sonja SUCIC, Oliver KUDLACEK (Vienna)
14:00–14:15
A37 Endotoxin-induced microparticle formation is subject to tolerance development in humans
Daniel Nguyen*, Stefan Weisshaar and Michael Wolzt (Vienna)
14:15–14:30
A46 Small-animal PET evaluation of [¹¹C]MC113 as a PET tracer for P-glycoprotein
Severin Mairinger*, Nicola A. Colabufo, Thomas Wanek, Claudia Kuntner, Johann Stanek, Thomas Erker, Mariangela Cantore, Francesco Berardi, Roberto Perrone, Markus Müller and Oliver Langer (Seibersdorf, Vienna, Bari)
14:30–14:45
A15 Molecular engineering of the TRPC3 pore structure identifies Ca²⁺ permeation through TRPC3 channels as a key determinant of cardiac calcineurin/NFAT signaling
Michaela Lichtenegger*, Hannes Schleifer, Thomas Stockner, Christoph Romanin, Michael Poteser and Klaus Groschner (Graz, Linz)
14:45–15:00
A38 Does VEGF polymorphism play a role in the treatment success with VEGF inhibitors in patients with CNV?
Agnes Boltz*, Günther Weigert, Stefan Palkovits, Manuel Ruiß, Martin Weger, Yosuf El-Shabrawi, Gerhard Garhöfer, Jost Jonas and Leopold SchmettererStefan Weisshaar and Michael Wolzt (Vienna, Graz, Mannheim)

PLENARY LECTURE
15:00–16:00 Chair: Michael FREISSMUTH (Vienna)
Giulio SUPERTI-FURGA
Director, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna
"Molecular networks and the mechanism of action of drugs"

COFFEE BREAK & STRUCTURED POSTER SESSION 2
16:00–18:00 Chairs: Maria Waldhoer (Graz), Christian NANOFF (Vienna)
Posters A10, A11, A12, A13, A14, A16, A17, A18, A19, A20, A21, A22, A26, A28, A29, A30, A31, A32, A34, A45, A47, A48, L1
(5 min per poster)

GENERAL ASSEMBLY of APHAR
18:00 General Assembly of APHAR
(APHAR Members only)
Teilnahmeberechtigt sind alle ordentlichen Mitglieder, sowie Vertreter der außerordentlichen Mitglieder. Stimmberechtigt sind nur die ordentlichen Mitglieder. Gem. § 9 der Statuten wird den Mitgliedern die vorläufige Tagesordnung spätestens vier Wochen vor der Generalversammlung zugeschickt. Weitere Anträge sind mindestens sieben Tage vor dem Termin der Versammlung beim Vorstand schriftlich einzureichen.
APHAR HEURIGER

19:30
APHAR Heuriger

Admittance for registered participants only.
Heuriger WELSER
Probusgasse 12
1190 Vienna (19th district)

(click on the map to enlarge)
Public transport: Take tram no. 37 (see map of meeting location above) in direction "Hohe Warte" and get off at the last stop. From there walk down Hohe Warte (keeping the direction of the tram line), cross Grinzinger Straße, enter Armbrustergasse, first right is Probusgasse.
Alternatively, you can take underground U4 until last stop Heiligenstadt, then take bus no. 38A until stop Armbrustergasse.

_________
19.11.2010

SHORT COMMUNICATIONS
08:30–10:00	6 Short Communications Chair: Markus ZEITLINGER, Anna BUCSICS (Vienna)
08:30–08:45 A1	The trafficking of GPR55 is regulated by the G protein-coupled receptor-associated sorting protein 1 Julia Kargl, Nariman Balenga, Wolfgang Platzer, Lene Martini, Jennifer Whistler and Maria Waldhoer* (Graz, San Francisco)
08:45–09:00 A5	Enhanced fear expression in a psychphathological mouse model of trait anxiety: pharmacological interventions Markus Hauschild, Simone B. Sartori, Mirjam Bunck, Stefano Gaburro, Rainer Landgraf and Nicolas Singewald* (Innsbruck, München, Martinsried)
09:00–09:15 A42	Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo Johannes Werzowa, Stefan Koehrer, Sabine Strommer, Daniel Cejka, Thorsten Füreder and Wacheck* (Vienna)
09:15–09:30 A43	Thrombus formation is not pH-dependent Stefan Weisshaar, Ghazaleh Gouya and Michael Wolzt* (Vienna)
09:30–09:45 A9	Is thymoquinone an antioxidant? Katrin Staniek and Lars Gille* (Vienna)
09:45–10:00 A44	Inhibition of tissue factor pathway inhibitor (TFPI) by ARC19499 improves clotting of hemophiliac blood Monika E. Gorczyca, Bernd Jilma, Christoph Male, Sylvia Reitter, James C. Gilbert and Ingrid Pabinger* (Vienna; Cambridge, MA)

COFFEE BREAK
10:00–10:15	Coffee Break

STRUCTURED POSTER SESSION 1
10:15–11:00	Chairs: Dagmar STOIBER-SAKAGUCHI, Jürgen ZEZULA (Vienna) Posters A4, A6, A8, A35, A36, A39, A40, A41 (5 min per poster)

PLENARY LECTURE
11:00–12:00	Chair: Brigitte BLÖCHL-DAUM (Vienna) John WARREN Medical Assessor at UK Medicines Healthcare Products Regulatory Agency (MHRA) and Member of EU Scientific Advice Working Party at the European Medicines Agency (EMA) "Drug Discovery: Lessons from Evolution"

LUNCH BREAK & FREE POSTER SESSION
12:00–14:00	Lunch Break & Free Poser Session
12:00	Mitgliederversammlung der Sektion Klinische Pharmakologie (nur für Mitglieder der Sektion)
SHORT COMMUNICATIONS
14:00–15:00	4 Short Communications Chairs: Sonja SUCIC, Oliver KUDLACEK (Vienna)
14:00–14:15 A37	Endotoxin-induced microparticle formation is subject to tolerance development in humans Daniel Nguyen, Stefan Weisshaar and Michael Wolzt* (Vienna)
14:15–14:30 A46	Small-animal PET evaluation of [¹¹C]MC113 as a PET tracer for P-glycoprotein Severin Mairinger, Nicola A. Colabufo, Thomas Wanek, Claudia Kuntner, Johann Stanek, Thomas Erker, Mariangela Cantore, Francesco Berardi, Roberto Perrone, Markus Müller and Oliver Langer* (Seibersdorf, Vienna, Bari)
14:30–14:45 A15	Molecular engineering of the TRPC3 pore structure identifies Ca²⁺ permeation through TRPC3 channels as a key determinant of cardiac calcineurin/NFAT signaling Michaela Lichtenegger, Hannes Schleifer, Thomas Stockner, Christoph Romanin, Michael Poteser and Klaus Groschner* (Graz, Linz)
14:45–15:00 A38	Does VEGF polymorphism play a role in the treatment success with VEGF inhibitors in patients with CNV? Agnes Boltz, Günther Weigert, Stefan Palkovits, Manuel Ruiß, Martin Weger, Yosuf El-Shabrawi, Gerhard Garhöfer, Jost Jonas and Leopold SchmettererStefan Weisshaar and Michael Wolzt* (Vienna, Graz, Mannheim)

PLENARY LECTURE
15:00–16:00	Chair: Michael FREISSMUTH (Vienna) Giulio SUPERTI-FURGA Director, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna "Molecular networks and the mechanism of action of drugs"

COFFEE BREAK & STRUCTURED POSTER SESSION 2
16:00–18:00	Chairs: Maria Waldhoer (Graz), Christian NANOFF (Vienna) Posters A10, A11, A12, A13, A14, A16, A17, A18, A19, A20, A21, A22, A26, A28, A29, A30, A31, A32, A34, A45, A47, A48, L1 (5 min per poster)

GENERAL ASSEMBLY of APHAR
18:00	General Assembly of APHAR (APHAR Members only) Teilnahmeberechtigt sind alle ordentlichen Mitglieder, sowie Vertreter der außerordentlichen Mitglieder. Stimmberechtigt sind nur die ordentlichen Mitglieder. Gem. § 9 der Statuten wird den Mitgliedern die vorläufige Tagesordnung spätestens vier Wochen vor der Generalversammlung zugeschickt. Weitere Anträge sind mindestens sieben Tage vor dem Termin der Versammlung beim Vorstand schriftlich einzureichen.
APHAR HEURIGER
19:30	*APHAR Heuriger* Admittance for registered participants only. Heuriger WELSER Probusgasse 12 1190 Vienna (19th district) (click on the map to enlarge) Public transport: Take tram no. 37 (see map of meeting location above) in direction "Hohe Warte" and get off at the last stop. From there walk down Hohe Warte (keeping the direction of the tram line), cross Grinzinger Straße, enter Armbrustergasse, first right is Probusgasse. Alternatively, you can take underground U4 until last stop Heiligenstadt, then take bus no. 38A until stop Armbrustergasse.