APHAR - Austrian Pharmacological Society - Österreichische Pharmakologische Gesellschaft

FRIDAY 26 Sept SATURDAY 27 Sept POSTERS
GENERAL INFORMATION ABSTRACTS SOCIAL PROGRAM

20th Scientific Symposium of
the Austrian Pharmacological Society APHAR
Innsbruck, 26–27 September 2014
POSTER PRESENTATIONS
Download print version of programme →
Abstracts will become available upon publication in Intrinsic Activity, 2014;2(Suppl.1). Publication date: 22 September 2014

POSTER PRESENTATIONS
Posters will be on display for the entire period of the meeting (Friday and Saturday). Presenting authors are requested to indicate their presence at their poster on the poster board (preferably during coffee breaks). Dimensions of the poster boards: A0 vertical.
A1.1 Decrypting the structure of LeuT_Aa employing luminescence resonance energy transfer (LRET)
Azmat Sohail, Kumaresan Jayaraman, SanthoshKannan Venkatesan, Oliver Kudlacek, Peggy S. Bergner, Gerhard Ecker, Michael Freissmuth, Klaus Wanner, Thomas Stockner, Walter Sandtner and Harald H. Sitte* (Vienna, Munich)
A1.2 Pharmacological stimulation of hematopoietic stem cells
Zahra Kazemi, Christian Balazs, Wolfgang Strohmaier, Michael Freissmuth and Eva Zebedin-Brandl* (Vienna, Junglinster)
A1.5 Role of histone acetylation and dopaminergic signalling in promoting long-term and context-independent fear extinction
Verena Maurer, Nigel Whittle, Johannes Rainer, Taras Valovka and Nicolas Singewald* (Innsbruck)
A1.7 Repeated water avoidance stress causes resilience against colitis-induced behavioural changes in mice
Hassan Ahmed, Piyush Jain, Florian Reichmann, Raphaela Mayerhofer, Aitak Farzi, Rufina Schuligoi and Peter Holzer* (Graz)
A1.9 Cytosolic heat shock proteins as key players in serotonin transporter folding
Ali El-Kasaby, Florian Koban, Harald H. Sitte, Michael Freissmuth and Sonja Sucic* (Vienna)
A1.10 Ca_V1.3 L-type calcium channel contribution to retinal activity
Verena Burtscher, Christof Kugler, Gerald J. Obermair, Jörg Striessnig, Klaus W. Schicker and Alexandra Koschak* (Vienna, Innsbruck)
A1.11 Signaling mechanisms of 5-HT₂ receptors in primary sensory neurons
Enkhbileg Gantumur, Arsalan Yousuf and Stefan Boehm* (Vienna)
A1.12 The role of hydrogen sulfide in autonomic nervous system
Manuel Domínguez Rodríguez, Isabella Salzer, Helmut Drobny, Giri Chandaka and Stefan Boehm* (Vienna)
A1.13 Transmembrane proteins of Fasciola hepatica: identification and characterization of new putative drug targets
Bulut Hamali, Maria Berenyi, Joachim Lipp, Oliver Kudlacek* and Silvia Fluch (Vienna, Tulln)
A1.14 Amphetamines and SERT: what’s the N-tail got to do with it?
Sonja Sucic, Harald H. Sitte and Michael Freissmuth* (Vienna)
A1.15 A1.15 Resveratrol and its derivative piceatannol modulate mitochondrial Ca²⁺ uptake via inhibition of ATP synthase
Corina Madreiter, Roland Malli and Wolfgang F. Graier* (Graz)
A1.16 Age-dependent sensitivity to glucocorticoids in the developing mouse basolateral nucleus of the amygdala
Peter Koppensteiner, Shu Aizawa, Daisuke Yamada, Tomohiro Kabuta, Stefan Boehm, Keiji Wada and Masayuki Sekiguchi* (Tokyo, Vienna, Saitama)
A1.17 Investigating the pharmacology of L-type Ca²⁺ channels using stable cell lines and brain activity patterns
Nadine J. Ortner, Petronel Tuluc, Thomas Ciossek, Andreas Lieb, Henning J. Draheim and Jörg Striessnig* (Innsbruck, Biberach)
A1.19 Anti-inflammatory and antinociceptive effects of a new peripherally acting μ opioid receptor agonist in experimental models of colitis in mice
Tanila Ben Haddou, Marta Sobczak, Jakub Fichna, Helmut Schmidhammer and Mariana Spetea* (Innsbruck, Łódź)
A1.20 Sewarine, an indole alkaloid from Rhazya stricta and a κ opioid receptor antagonist, induces apoptosis via caspase activation in various cancer cell lines, and inhibits NF-κB activation
Aquilino Lantero, Stefan Salcher, Petra Obexer and Mariana Spetea* (Innsbruck)
A1.23 The effects of the neurosteroid dehydroepiandrosterone on rat behavior in the forced swim test
Janko Samardžić*, Dubravka Švob Štrac, Miloš Djurić and Dragan I. Obradović (Belgrade, Zagreb)
A1.24 What is the somatodendritic serotonin transporter good for?
Ameya Kasture, Sonja Sucic, Ali El-Kasaby, Florian Koban and Michael Freissmuth* (Vienna)
A1.25 Pharmacological properties of rosemary essential oil in experimental animals
Aleksandar Rašković, Isidora Milanović, Ivana Gluvnja, Nebojša Pavlović, Boris Milijašević* and Momir Mikov (Novi Sad, Zemun)
A1.26 Investigating the molecular mechanisms underlying the differential subcellular targeting of the metabotropic glutamate receptor 1 in the cerebellar cortex
Mahnaz Mansouri, Herbet Lindner and Francesco Ferraguti* (Innsbruck)
A1.29 Analyzing the role of diffusion for A_2A receptor function in hippocampal neurons
Patrick Thurner, Ingrid Gsandtner, Oliver Kudlacek, Daniel Choquet, Christian Nanoff, Michael Freissmuth and Jürgen Zezula* (Vienna, Bordeaux)
A1.31 Region-specific differences in the activity of mitochondrial complexes I and II in the mouse brain
Johannes Burtscher*, Juliane Heidler, Erich Gnaiger and Christoph Schwarzer (Innsbruck)
A1.32 Cellular and subcellular localization of metabotropic glutamate (mGlu) receptor 4 in the rodent amygdala
Sara Ferrazzo and Francesco Ferraguti* (Innsbruck)
A1.33 Connectivity of CR⁺ (VIP⁺) interneurons in the basolateral amygdala
Enrica Paradiso, Chun Xu, Andreas Lüthi and Francesco Ferraguti* (Innsbruck)
A1.34 Cardiac ion channel profile of the antiepileptic drug retigabine
Lena Rubi, Michael Kovar, Xaver Koenig and Karlheinz Hilber* (Vienna)
A1.35 Suggested role of MKP-1 in regulation of the inflammatory response in a human intestinal epithelia cell (Caco-2) model
Mohammad R. Lornejad-Schäfer and Christine Schäfer* (Linz)
A1.36 Successful rescue of impaired fear extinction leads to dynamic regulation of microRNAs in the amygdala
Conor Murphy, Ronald Gstir, Verena Maurer, Simon Schafferer, Nigel Whittle, Alexander Hüttenhofer and Nicolas Singewald* (Innsbruck)
A1.37 Effects of two different surface coatings of superparamagnetic iron oxide nanoparticles on membrane properties in a human intestinal barrier model
Mohammad R. Lornejad-Schäfer*, Christina Janko, Jan Zaloga, Rainer Tietze, Klaus R. Schröder and Christine Schäfer (Linz, Erlangen)
A1.38 Comparative application of common virtual screening tools for the identification of novel μ opioid receptor agonists and antagonists
Teresa Kaserer, Mariana Spetea, Helmut Schmidhammer and Daniela Schuster* (Innsbruck)
A1.39 Changes in the expression of histone deacetylase 1–11 mRNAs in the hippocampus in two mouse models of temporal lobe epilepsy
Rohan Jagirdar, Meinrad Drexel, Ramon O. Tasan and Günther Sperk* (Innsbruck)
A1.40 The role of neurokinin-B-expressing neurons in the basolateral amygdala in fear conditioning and extinction
Gilliard Lach, James Wood, Stefan Weger, Regine Heilbronn, Peer Wulff, Günther Sperk and Ramon Tasan* (Innsbruck, Berlin, Kiel)
A1.42 Presynaptic NPY Y₂ receptors reduce GABAergic neurotransmission within the central extended amygdala
James Wood, Gilliard Lach, Dilip Verma, Herbert Herzog, Günther Sperk and Ramon O. Tasan* (Innsbruck, Sydney)
A1.43 Development of epilepsy after spatially restricted viral-vector-mediated silencing of parvalbumin-expressing GABAergic interneurons in the mouse
Meinrad Drexel*, Stefan Weger, Regine Heilbronn, Peer Wulff, Ramon Tasan and Günther Sperk (Innsbruck, Berlin, Kiel)
Unpublished presentations:
X1.1 Secretory phospholipase A₂-modified HDL shows potent anti-inflammatory effects on neutrophils
Sanja Ćurčić, Michael Holzer, Robert Frei, Lisa Pasterk, Saša Frank, Ákos Heinemann and Gunther Marsche* (Graz)
X1.3 Toward developing the full energy profile of substrate transport of the leucine transporter (LeuT) using steered molecular dynamics simulations
Kumaresan Jayaraman, Harald H. Sitte and Thomas Stockner* (Vienna)
X1.4 The atypical cannabinoid receptor GPR55 plays a proinflammatory role in experimental colitis
Angela Stančić, Ákos Heinemann, Rufina Schuligoi and Rudolf Schicho* (Graz)
X1.5 Circular plant peptides as immunosuppressive treatment against experimental autoimmune encephalomyelitis
Kathrin Thell, Roland Hellinger, Emine Sahin, Carsten Gründemann, Gernot Schabbauer and Christian W. Gruber* (Vienna)
X1.6 Liver cirrhosis is associated with reduced anti-inflammatory capacity of serum: central role of high-density lipoproteins
Markus Trieb, Angela Horvath, Vanessa Stadlbauer, Lisa Pasterk and Gunther Marsche* (Graz)
X1.7 Uremia-induced oxidative modifications convert plasma albumin into platelet activators
Lisa Pasterk, MarkusTrieb, Sanja Ćurčić, Ákos Heinemann and Gunther Marsche* (Graz)
X1.8 The role of the prostaglandin D₂ receptors DP and CRTH2 in transcription factor activation and eosinophil biology
Miriam Peinhaupt, Miriam Sedej and Ákos Heinemann* (Graz)
X1.11 Human Ca_V1.3 (CACNA1D) calcium channel mutations associated with hyperaldosteronism or autism risk
Alexandra Pinggera, Andreas Lieb, Stefania Monteleone, Elena A. Azizan, Morris J. Brown, Klaus R. Liedl, Petronel Tuluc and Jörg Striessnig* (Innsbruck, Cambridge)
X1.14 Pharmacological characterization of novel oxytocin / vasopressin-like peptides from invertebrates
Maria Giulia Di Giglio and Christian W. Gruber* (Vienna)
X1.15 On the implication of L-type calcium channel-dependent conductances in hippocampal discharge activity
Manuel Ruiss, Stefan Boehm and Helmut Kubista* (Vienna)

APHAR Section of Clinical Pharmacology
Presenting author underlined, *denotes corresponding author
Unpublished presentations:
X2.2 Killing of selected antifungal drugs is inhibited by pulmonary surfactant in vitro
Peter Matzneller, Sabine Strommer, Dieter Mitteregger and Markus Zeitlinger* (Vienna)
X2.4 Antithrombotic triple therapy and coagulation activation at the site of thrombus formation: a randomized trial in healthy subjects
Stefan Weisshaar, Brigitte Litschauer, Ghazaleh Gouya, Philipp Mayer, Lukas Smerda, Stylianos Kapiotis, Paul A. Kyrle, Sabine Eichinger and Michael Wolzt* (Vienna)

_________
29.09.2014

FRIDAY 26 Sept	SATURDAY 27 Sept	POSTERS
GENERAL INFORMATION	ABSTRACTS	SOCIAL PROGRAM


POSTER PRESENTATIONS
Posters will be on display for the entire period of the meeting (Friday and Saturday). Presenting authors are requested to indicate their presence at their poster on the poster board (preferably during coffee breaks). Dimensions of the poster boards: A0 vertical.
A1.1	Decrypting the structure of LeuT_Aa employing luminescence resonance energy transfer (LRET) Azmat Sohail, Kumaresan Jayaraman, SanthoshKannan Venkatesan, Oliver Kudlacek, Peggy S. Bergner, Gerhard Ecker, Michael Freissmuth, Klaus Wanner, Thomas Stockner, Walter Sandtner and Harald H. Sitte* (Vienna, Munich)
A1.2	Pharmacological stimulation of hematopoietic stem cells Zahra Kazemi, Christian Balazs, Wolfgang Strohmaier, Michael Freissmuth and Eva Zebedin-Brandl* (Vienna, Junglinster)
A1.5	Role of histone acetylation and dopaminergic signalling in promoting long-term and context-independent fear extinction Verena Maurer, Nigel Whittle, Johannes Rainer, Taras Valovka and Nicolas Singewald* (Innsbruck)
A1.7	Repeated water avoidance stress causes resilience against colitis-induced behavioural changes in mice Hassan Ahmed, Piyush Jain, Florian Reichmann, Raphaela Mayerhofer, Aitak Farzi, Rufina Schuligoi and Peter Holzer* (Graz)
A1.9	Cytosolic heat shock proteins as key players in serotonin transporter folding Ali El-Kasaby, Florian Koban, Harald H. Sitte, Michael Freissmuth and Sonja Sucic* (Vienna)
A1.10	Ca_V1.3 L-type calcium channel contribution to retinal activity Verena Burtscher, Christof Kugler, Gerald J. Obermair, Jörg Striessnig, Klaus W. Schicker and Alexandra Koschak* (Vienna, Innsbruck)
A1.11	Signaling mechanisms of 5-HT₂ receptors in primary sensory neurons Enkhbileg Gantumur, Arsalan Yousuf and Stefan Boehm* (Vienna)
A1.12	The role of hydrogen sulfide in autonomic nervous system Manuel Domínguez Rodríguez, Isabella Salzer, Helmut Drobny, Giri Chandaka and Stefan Boehm* (Vienna)
A1.13	*Transmembrane proteins of Fasciola hepatica:* identification and characterization of new putative drug targets** Bulut Hamali, Maria Berenyi, Joachim Lipp, Oliver Kudlacek and Silvia Fluch* (Vienna, Tulln)
A1.14	Amphetamines and SERT: what’s the N-tail got to do with it? Sonja Sucic, Harald H. Sitte and Michael Freissmuth* (Vienna)
A1.15 A1.15	Resveratrol and its derivative piceatannol modulate mitochondrial Ca²⁺ uptake via inhibition of ATP synthase Corina Madreiter, Roland Malli and Wolfgang F. Graier* (Graz)
A1.16	Age-dependent sensitivity to glucocorticoids in the developing mouse basolateral nucleus of the amygdala Peter Koppensteiner, Shu Aizawa, Daisuke Yamada, Tomohiro Kabuta, Stefan Boehm, Keiji Wada and Masayuki Sekiguchi* (Tokyo, Vienna, Saitama)
A1.17	Investigating the pharmacology of L-type Ca²⁺ channels using stable cell lines and brain activity patterns Nadine J. Ortner, Petronel Tuluc, Thomas Ciossek, Andreas Lieb, Henning J. Draheim and Jörg Striessnig* (Innsbruck, Biberach)
A1.19	Anti-inflammatory and antinociceptive effects of a new peripherally acting μ opioid receptor agonist in experimental models of colitis in mice Tanila Ben Haddou, Marta Sobczak, Jakub Fichna, Helmut Schmidhammer and Mariana Spetea* (Innsbruck, Łódź)
A1.20	*Sewarine, an indole alkaloid from Rhazya stricta* and a κ opioid receptor antagonist, induces apoptosis via caspase activation in various cancer cell lines, and inhibits NF-κB activation** Aquilino Lantero, Stefan Salcher, Petra Obexer and Mariana Spetea* (Innsbruck)
A1.23	The effects of the neurosteroid dehydroepiandrosterone on rat behavior in the forced swim test Janko Samardžić, Dubravka Švob Štrac, Miloš Djurić and Dragan I. Obradović* (Belgrade, Zagreb)
A1.24	What is the somatodendritic serotonin transporter good for? Ameya Kasture, Sonja Sucic, Ali El-Kasaby, Florian Koban and Michael Freissmuth* (Vienna)
A1.25	Pharmacological properties of rosemary essential oil in experimental animals Aleksandar Rašković, Isidora Milanović, Ivana Gluvnja, Nebojša Pavlović, Boris Milijašević and Momir Mikov* (Novi Sad, Zemun)
A1.26	Investigating the molecular mechanisms underlying the differential subcellular targeting of the metabotropic glutamate receptor 1 in the cerebellar cortex Mahnaz Mansouri, Herbet Lindner and Francesco Ferraguti* (Innsbruck)
A1.29	Analyzing the role of diffusion for A_2A receptor function in hippocampal neurons Patrick Thurner, Ingrid Gsandtner, Oliver Kudlacek, Daniel Choquet, Christian Nanoff, Michael Freissmuth and Jürgen Zezula* (Vienna, Bordeaux)
A1.31	Region-specific differences in the activity of mitochondrial complexes I and II in the mouse brain Johannes Burtscher, Juliane Heidler, Erich Gnaiger and Christoph Schwarzer* (Innsbruck)
A1.32	Cellular and subcellular localization of metabotropic glutamate (mGlu) receptor 4 in the rodent amygdala Sara Ferrazzo and Francesco Ferraguti* (Innsbruck)
A1.33	Connectivity of CR⁺ (VIP⁺) interneurons in the basolateral amygdala Enrica Paradiso, Chun Xu, Andreas Lüthi and Francesco Ferraguti* (Innsbruck)
A1.34	Cardiac ion channel profile of the antiepileptic drug retigabine Lena Rubi, Michael Kovar, Xaver Koenig and Karlheinz Hilber* (Vienna)
A1.35	Suggested role of MKP-1 in regulation of the inflammatory response in a human intestinal epithelia cell (Caco-2) model Mohammad R. Lornejad-Schäfer and Christine Schäfer* (Linz)
A1.36	Successful rescue of impaired fear extinction leads to dynamic regulation of microRNAs in the amygdala Conor Murphy, Ronald Gstir, Verena Maurer, Simon Schafferer, Nigel Whittle, Alexander Hüttenhofer and Nicolas Singewald* (Innsbruck)
A1.37	Effects of two different surface coatings of superparamagnetic iron oxide nanoparticles on membrane properties in a human intestinal barrier model Mohammad R. Lornejad-Schäfer, Christina Janko, Jan Zaloga, Rainer Tietze, Klaus R. Schröder and Christine Schäfer* (Linz, Erlangen)
A1.38	Comparative application of common virtual screening tools for the identification of novel μ opioid receptor agonists and antagonists Teresa Kaserer, Mariana Spetea, Helmut Schmidhammer and Daniela Schuster* (Innsbruck)
A1.39	Changes in the expression of histone deacetylase 1–11 mRNAs in the hippocampus in two mouse models of temporal lobe epilepsy Rohan Jagirdar, Meinrad Drexel, Ramon O. Tasan and Günther Sperk* (Innsbruck)
A1.40	The role of neurokinin-B-expressing neurons in the basolateral amygdala in fear conditioning and extinction Gilliard Lach, James Wood, Stefan Weger, Regine Heilbronn, Peer Wulff, Günther Sperk and Ramon Tasan* (Innsbruck, Berlin, Kiel)
A1.42	Presynaptic NPY Y₂ receptors reduce GABAergic neurotransmission within the central extended amygdala James Wood, Gilliard Lach, Dilip Verma, Herbert Herzog, Günther Sperk and Ramon O. Tasan* (Innsbruck, Sydney)
A1.43	Development of epilepsy after spatially restricted viral-vector-mediated silencing of parvalbumin-expressing GABAergic interneurons in the mouse Meinrad Drexel, Stefan Weger, Regine Heilbronn, Peer Wulff, Ramon Tasan and Günther Sperk* (Innsbruck, Berlin, Kiel)
Unpublished presentations:
X1.1	Secretory phospholipase A₂-modified HDL shows potent anti-inflammatory effects on neutrophils Sanja Ćurčić, Michael Holzer, Robert Frei, Lisa Pasterk, Saša Frank, Ákos Heinemann and Gunther Marsche* (Graz)
X1.3	Toward developing the full energy profile of substrate transport of the leucine transporter (LeuT) using steered molecular dynamics simulations Kumaresan Jayaraman, Harald H. Sitte and Thomas Stockner* (Vienna)
X1.4	The atypical cannabinoid receptor GPR55 plays a proinflammatory role in experimental colitis Angela Stančić, Ákos Heinemann, Rufina Schuligoi and Rudolf Schicho* (Graz)
X1.5	Circular plant peptides as immunosuppressive treatment against experimental autoimmune encephalomyelitis Kathrin Thell, Roland Hellinger, Emine Sahin, Carsten Gründemann, Gernot Schabbauer and Christian W. Gruber* (Vienna)
X1.6	Liver cirrhosis is associated with reduced anti-inflammatory capacity of serum: central role of high-density lipoproteins Markus Trieb, Angela Horvath, Vanessa Stadlbauer, Lisa Pasterk and Gunther Marsche* (Graz)
X1.7	Uremia-induced oxidative modifications convert plasma albumin into platelet activators Lisa Pasterk, MarkusTrieb, Sanja Ćurčić, Ákos Heinemann and Gunther Marsche* (Graz)
X1.8	The role of the prostaglandin D₂ receptors DP and CRTH2 in transcription factor activation and eosinophil biology Miriam Peinhaupt, Miriam Sedej and Ákos Heinemann* (Graz)
X1.11	*Human Ca_V1.3 (CACNA1D) calcium channel mutations associated with hyperaldosteronism or autism risk* Alexandra Pinggera, Andreas Lieb, Stefania Monteleone, Elena A. Azizan, Morris J. Brown, Klaus R. Liedl, Petronel Tuluc and Jörg Striessnig* (Innsbruck, Cambridge)
X1.14	Pharmacological characterization of novel oxytocin / vasopressin-like peptides from invertebrates Maria Giulia Di Giglio and Christian W. Gruber* (Vienna)
X1.15	On the implication of L-type calcium channel-dependent conductances in hippocampal discharge activity Manuel Ruiss, Stefan Boehm and Helmut Kubista* (Vienna)
APHAR Section of Clinical Pharmacology
Presenting author underlined, denotes corresponding author*
Unpublished presentations:
X2.2	Killing of selected antifungal drugs is inhibited by pulmonary surfactant in vitro Peter Matzneller, Sabine Strommer, Dieter Mitteregger and Markus Zeitlinger* (Vienna)
X2.4	Antithrombotic triple therapy and coagulation activation at the site of thrombus formation: a randomized trial in healthy subjects Stefan Weisshaar, Brigitte Litschauer, Ghazaleh Gouya, Philipp Mayer, Lukas Smerda, Stylianos Kapiotis, Paul A. Kyrle, Sabine Eichinger and Michael Wolzt* (Vienna)