FRIDAY 26 Sept SATURDAY 27 Sept POSTERS
GENERAL INFORMATION ABSTRACTS SOCIAL PROGRAM

20th Scientific Symposium of
the Austrian Pharmacological Society APHAR

Innsbruck, 26–27 September 2014

LIST OF SUBMITTED ABSTRACTS

Abstracts will be published online on 22 September 2014 in Intrinsic Activity, the online, open-access publication medium of the Austrian Pharmacological Society, 2014; 2(Suppl.1)


click icon above for pdf file of all abstracts

Austrian Pharmacological Society (APHAR)
Presenting author underlined, *denotes corresponding author
A1.1 Decrypting the structure of LeuTAa employing luminescence resonance energy transfer (LRET)
Azmat Sohail, Kumaresan Jayaraman, SanthoshKannan Venkatesan, Oliver Kudlacek, Peggy S. Bergner, Gerhard Ecker, Michael Freissmuth, Klaus Wanner, Thomas Stockner, Walter Sandtner and Harald H. Sitte* (Vienna, Munich)
A1.2 Pharmacological stimulation of hematopoietic stem cells
Zahra Kazemi, Christian Balazs, Wolfgang Strohmaier, Michael Freissmuth and Eva Zebedin-Brandl* (Vienna, Junglinster)
A1.3 In vivo analysis of cytotoxic effects of alpha-tocopheryl succinate in Ehrlich ascites carcinoma
Bojan Stanimirov*, Karmen Stankov, Nebojša Pavlović, Maja Stojančević, Dunja Mihajlović, Sunčica Stankov and Momir Mikov (Novi Sad)
A1.4 Potential role of K+ currents in the repolarization reserve: the importance of cardiac repolarization reserve in understanding the proarrhythmic side effects of antiarrhythmic drugs
Norbert Jost*, Danina M. Muntean and András Varró (Szeged, Timișoara)
A1.5 Role of histone acetylation and dopaminergic signalling in promoting long-term and context-independent fear extinction
Verena Maurer, Nigel Whittle, Johannes Rainer, Taras Valovka and Nicolas Singewald* (Innsbruck)
A1.6 The influence of the intestinal environment in drug bioavailability
Maja Stojančević*, Bojan Stanimirov, Nebojša Pavlović, Hani Al-Salami, Svetlana Goločorbin-Kon and Momir Mikov (Novi Sad, Perth)
A1.7 Repeated water avoidance stress causes resilience against colitis-induced behavioural changes in mice
Hassan Ahmed, Piyush Jain, Florian Reichmann, Raphaela Mayerhofer, Aitak Farzi, Rufina Schuligoi and Peter Holzer* (Graz)
A1.8 Retinal morphology of a CaV1.4 mouse model for congenital stationary night blindness type 2
Dagmar Knoflach, Vasily Kerov, Gerald J. Obermair, Martin Glösmann, Klaus W. Schicker, Amy Lee and Alexandra Koschak* (Graz)
A1.9 Cytosolic heat shock proteins as key players in serotonin transporter folding
Ali El-Kasaby, Florian Koban, Harald H. Sitte, Michael Freissmuth and Sonja Sucic* (Vienna)
A1.10 CaV1.3 L-type calcium channel contribution to retinal activity
Verena Burtscher, Christof Kugler, Gerald J. Obermair, Jörg Striessnig, Klaus W. Schicker and Alexandra Koschak* (Vienna, Innsbruck)
A1.11 Signaling mechanisms of 5-HT2 receptors in primary sensory neurons
Enkhbileg Gantumur, Arsalan Yousuf and Stefan Boehm* (Vienna)
A1.12 The role of hydrogen sulfide in autonomic nervous system
Manuel Domínguez  Rodríguez, Isabella Salzer, Helmut Drobny, Giri Chandaka and Stefan Boehm* (Vienna)
A1.13 Transmembrane proteins of Fasciola hepatica: identification and characterization of new putative drug targets
Bulut Hamali, Maria Berenyi, Joachim Lipp, Oliver Kudlacek* and Silvia Fluch (Vienna, Tulln)
A1.14 Amphetamines and SERT: what’s the N-tail got to do with it?
Sonja Sucic, Harald H. Sitte and Michael Freissmuth* (Vienna)
A1.15 Resveratrol and its derivative piceatannol modulate mitochondrial Ca2+ uptake via inhibition of ATP synthase
Corina Madreiter, Roland Malli and Wolfgang F. Graier* (Graz)
A1.16 Age-dependent sensitivity to glucocorticoids in the developing mouse basolateral nucleus of the amygdala
Peter Koppensteiner, Shu Aizawa, Daisuke Yamada, Tomohiro Kabuta, Stefan Boehm, Keiji Wada and Masayuki Sekiguchi* (Tokyo, Vienna, Saitama)
A1.17 Investigating the pharmacology of L-type Ca2+ channels using stable cell lines and brain activity patterns
Nadine J. Ortner, Petronel Tuluc, Thomas Ciossek, Andreas Lieb, Henning J. Draheim and Jörg Striessnig* (Innsbruck, Biberach)
A1.18 Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators
Nadine J. Ortner, Gabriella Bock, David H. F. Vandael, Robert Mauersberger, Henning J. Draheim, Ronald Gust, Emilio Carbone, Petronel Tuluc and Jörg Striessnig* (Innsbruck, Torino, Biberach)
A1.19 Anti-inflammatory and antinociceptive effects of a new peripherally acting μ opioid receptor agonist in experimental models of colitis in mice
Tanila Ben Haddou, Marta Sobczak, Jakub Fichna, Helmut Schmidhammer and Mariana Spetea* (Innsbruck, Łódź)
A1.20 Sewarine, an indole alkaloid from Rhazya stricta and a κ opioid receptor antagonist, induces apoptosis via caspase activation in various cancer cell lines, and inhibits NF-κB activation
Aquilino Lantero, Stefan Salcher, Petra Obexer and Mariana Spetea* (Innsbruck)
A1.21 Diphenethylamine derivatives, a novel class of κ opioid receptor ligands: molecular modeling, synthesis and pharmacological activities
Elena Guerrieri, Marcel Bermudez, Jayapal R. Mallareddy, Ilona P. Berzetei-Gurske, Gerhard Wolber, Géza Tóth, Helmut Schmidhammer and Mariana Spetea* (Innsbruck, Berlin, Szeged, Menlo Park)
A1.22 The C-terminus of SERT provides distinct motifs for ER export and protein folding
Florian Koban, Sonja Sucic, Ali El-Kasaby, Harald H. Sitte and Michael Freissmuth* (Vienna)
A1.23 The effects of the neurosteroid dehydroepiandrosterone on rat behavior in the forced swim test
Janko Samardžić*, Dubravka Švob Štrac, Miloš Djurić and Dragan I. Obradović (Belgrade, Zagreb)
A1.24 What is the somatodendritic serotonin transporter good for?
Ameya Kasture, Sonja Sucic, Ali El-Kasaby, Florian Koban and Michael Freissmuth* (Vienna)
A1.25 Pharmacological properties of rosemary essential oil in experimental animals
Aleksandar Rašković, Isidora Milanović, Ivana Gluvnja, Nebojša Pavlović, Boris Milijašević* and Momir Mikov (Novi Sad, Zemun)
A1.26 Investigating the molecular mechanisms underlying the differential subcellular targeting of the metabotropic glutamate receptor 1 in the cerebellar cortex
Mahnaz Mansouri, Herbet Lindner and Francesco Ferraguti* (Innsbruck)
A1.27 Activation of kappa opioid receptors reduces seizure activity in a mouse model of temporal lobe epilepsy
Luca Zangrandi, Johannes Burtscher and Christoph Schwarzer* (Innsbruck)
A1.28 Histone deacetylase inhibitors rescue impaired fear extinction in a persistent and context-independent manner
Nigel Whittle*, Verena Maurer, Taras Valovka and Nicolas Singewald* (Innsbruck)
A1.29 Analyzing the role of diffusion for A2A receptor function in hippocampal neurons
Patrick Thurner, Ingrid Gsandtner, Oliver Kudlacek, Daniel Choquet, Christian Nanoff, Michael Freissmuth and Jürgen Zezula* (Vienna, Bordeaux)
A1.30 The anticonvulsant retigabine is a subtype selective modulator of GABAA receptors
Marco Treven, Xaver Koenig, Elham Assadpour, Enkhbileg Gantumur, Karlheinz Hilber, Stefan Boehm* and Helmut Kubista (Vienna)
A1.31 Region-specific differences in the activity of mitochondrial complexes I and II in the mouse brain
Johannes Burtscher*, Juliane Heidler, Erich Gnaiger and Christoph Schwarzer (Innsbruck)
A1.32 Cellular and subcellular localization of metabotropic glutamate (mGlu) receptor 4 in the rodent amygdala
Sara Ferrazzo and Francesco Ferraguti* (Innsbruck)
A1.33 Connectivity of CR+ (VIP+) interneurons in the basolateral amygdala
Enrica Paradiso, Chun Xu, Andreas Lüthi and Francesco Ferraguti* (Innsbruck)
A1.34 Cardiac ion channel profile of the antiepileptic drug retigabine
Lena Rubi, Michael Kovar, Xaver Koenig and Karlheinz Hilber* (Vienna)
A1.35 Suggested role of MKP-1 in regulation of the inflammatory response in a human intestinal epithelia cell (Caco-2) model
Mohammad R. Lornejad-Schäfer and Christine Schäfer* (Linz)
A1.36 Successful rescue of impaired fear extinction leads to dynamic regulation of microRNAs in the amygdala
Conor Murphy, Ronald Gstir, Verena Maurer, Simon Schafferer, Nigel Whittle, Alexander Hüttenhofer and Nicolas Singewald* (Innsbruck)
A1.37 Effects of two different surface coatings of superparamagnetic iron oxide nanoparticles on membrane properties in a human intestinal barrier model
Mohammad R. Lornejad-Schäfer*, Christina Janko, Jan Zaloga, Rainer Tietze, Klaus R. Schröder and Christine Schäfer (Linz, Erlangen)
A1.38 Comparative application of common virtual screening tools for the identification of novel μ opioid receptor agonists and antagonists
Teresa Kaserer, Mariana Spetea, Helmut Schmidhammer and Daniela Schuster* (Innsbruck)
A1.39 Changes in the expression of histone deacetylase 1–11 mRNAs in the hippocampus in two mouse models of temporal lobe epilepsy
Rohan Jagirdar, Meinrad Drexel, Ramon O. Tasan and Günther Sperk* (Innsbruck)
A1.40 The role of neurokinin-B-expressing neurons in the basolateral amygdala in fear conditioning and extinction
Gilliard Lach, James Wood, Stefan Weger, Regine Heilbronn, Peer Wulff, Günther Sperk and Ramon Tasan* (Innsbruck, Berlin, Kiel)
A1.41 Modulation of survival circuits in extinction of conditioned fear
Dilip Verma, James Wood, Gilliard Lach, Herbert Herzog, Günther Sperk and Ramon O. Tasan* (Innsbruck, Sydney)
A1.42 Presynaptic NPY Y2 receptors reduce GABAergic neurotransmission within the central extended amygdala
James Wood, Gilliard Lach, Dilip Verma, Herbert Herzog, Günther Sperk and Ramon O. Tasan* (Innsbruck, Sydney)
A1.43 Development of epilepsy after spatially restricted viral-vector-mediated silencing of parvalbumin-expressing GABAergic interneurons in the mouse
Meinrad Drexel*, Stefan Weger, Regine Heilbronn, Peer Wulff, Ramon Tasan and Günther Sperk (Innsbruck, Berlin, Kiel)
Unpublished presentations:
X1.1 Secretory phospholipase A2-modified HDL shows potent anti-inflammatory effects on neutrophils
Sanja Ćurčić, Michael Holzer, Robert Frei, Lisa Pasterk, Saša Frank, Ákos Heinemann and Gunther Marsche* (Graz)
X1.2 Real-time uptake of fluorescent ASP+ via the organic cation transporter 3
Felix P. Mayer, Diethart Schmid, Marion Holy, Jae-Won Yang, Isabella Salzer, Stefan Boehm, Peter Chiba and Harald H. Sitte* (Vienna)
X1.3 Toward developing the full energy profile of substrate transport of the leucine transporter (LeuT) using steered molecular dynamics simulations
Kumaresan Jayaraman, Harald H. Sitte and Thomas Stockner* (Vienna)
X1.4 The atypical cannabinoid receptor GPR55 plays a proinflammatory role in experimental colitis
Angela Stančić, Ákos Heinemann, Rufina Schuligoi and Rudolf Schicho* (Graz)
X1.5 Circular plant peptides as immunosuppressive treatment against experimental autoimmune encephalomyelitis
Kathrin Thell, Roland Hellinger, Emine Sahin, Carsten Gründemann, Gernot Schabbauer and Christian W. Gruber* (Vienna)
X1.6 Liver cirrhosis is associated with reduced anti-inflammatory capacity of serum: central role of high-density lipoproteins
Markus Trieb, Angela Horvath, Vanessa Stadlbauer, Lisa Pasterk and Gunther Marsche* (Graz)
X1.7 Uremia-induced oxidative modifications convert plasma albumin into platelet activators
Lisa Pasterk, MarkusTrieb, Sanja Ćurčić, Ákos Heinemann and Gunther Marsche* (Graz)
X1.8 The role of the prostaglandin D2 receptors DP and CRTH2 in transcription factor activation and eosinophil biology
Miriam Peinhaupt, Miriam Sedej and Ákos Heinemann* (Graz)
X1.9 Target deconvolution of immunosuppressive plant peptides
Roland Hellinger, Kathrin Thell, Gernot Schabbauer and Christian W. Gruber* (Vienna)
X1.10 Prostaglandin E2 EP4 receptor prevents acute lung injury via enhancing pulmonary microvascular barrier function
Jovana Marić, Viktória Kónya, Katharina Jandl, Petra Luschnig, Ilse Lanz, Wolfgang Platzer, Rufina Schuligoi and Ákos Heinemann* (Graz)
X1.11 Human CaV1.3 (CACNA1D) calcium channel mutations associated with hyperaldosteronism or autism risk
Alexandra Pinggera, Andreas Lieb, Stefania Monteleone, Elena A. Azizan, Morris J. Brown, Klaus R. Liedl, Petronel Tuluc and Jörg Striessnig* (Innsbruck, Cambridge)
X1.12 Equilibrium conformation of substrate releasing state of P-glycoprotein in a membrane environment
Thomas Stockner*, Yaprak Dönmez Çakıl and Peter Chiba (Vienna)
X1.13 Altered epigenetic mechanisms in the cingulate cortex are associated with bidirectional modulation of innate anxiety-like behavior
Anupam Sah, Sergey V. Sotnikov, Maria Kharitonova, Nigel Whittle, Rainer Landgraf and Nicolas Singewald* (Innsbruck, Munich)
X1.14 Pharmacological characterization of novel oxytocin / vasopressin-like peptides from invertebrates
Maria Giulia Di Giglio and Christian W. Gruber* (Vienna)
X1.15 On the implication of L-type calcium channel-dependent conductances in hippocampal discharge activity
Manuel Ruiss, Stefan Boehm and Helmut Kubista* (Vienna)
APHAR Section of Clinical Pharmacology
Presenting author underlined, *denotes corresponding author
A2.1 Biliary amphotericin B pharmacokinetics and pharmacodynamics
René Welte, Stephan Eschertzhuber, Sandra Leitner-Rupprich, Maria Aigner, Cornelia Lass-Flörl, Stefan Weiler, Eva Stienecke, Rosa Bellmann-Weiler, Michael Joannidis and Romuald Bellmann* (Innsbruck)
Unpublished presentations:
X2.1 Single and repeated dose pharmacokinetics of ceftaroline in plasma and soft tissues of healthy volunteers for two different dosing regimens of ceftaroline fosamil
Peter Matzneller, Edith Lackner, Paul Severin and Markus Zeitlinger* (Vienna, Madison WI)
X2.2 Killing of selected antifungal drugs is inhibited by pulmonary surfactant in vitro
Peter Matzneller, Sabine Strommer, Dieter Mitteregger and Markus Zeitlinger* (Vienna)
X2.3 Absorption kinetics of low-dose chewable aspirin: implications for acute coronary syndromes
Eva-Luise Hobl, Rainer W. Schmid, Thomas Stimpfl, Josef Ebner and Bernd Jilma* (Vienna)
X2.4 Antithrombotic triple therapy and coagulation activation at the site of thrombus formation: a randomized trial in healthy subjects
Stefan Weisshaar, Brigitte Litschauer, Ghazaleh Gouya, Philipp Mayer, Lukas Smerda, Stylianos Kapiotis, Paul A. Kyrle, Sabine Eichinger and Michael Wolzt* (Vienna)
X2.5 Effect of antioxidant supplementation on oxygen-induced retinal vasoconstriction in an inflammatory model in humans
Doreen Schmidl, Reinhard Told, Stefan Palkovits, Gerhard Garhöfer and Leopold Schmetterer* (Vienna, Graz)
Education and Training in Pharmacology
Presenting author underlined, *denotes corresponding author
A3.1 European Certified Pharmacologists (EuCP): standards for postgraduate professional training in pharmacology established by EPHAR, the Federation of European Pharmacological Societies
Thomas Griesbacher* and Filippo Drago (Graz, Catania)
A3.2 LifeTrain: towards a European framework for continuing professional development in biomedical sciences
Michael Wolzt, Mike Hardman, Christa Janko*, Hans H. Lindén and Cath Brooksbank (Vienna, Manchester, Stockholm), Cambridge
A3.3 on-course®: a portal for in-service training and career development for biomedical scientists
Christa Janko*, Mike Hardman, Antony Payton, Pavel Dallakian and Michael Wolzt (Vienna, Manchester)
A3.4 on-course®: a research tool for analysing cross-sectional and longitudinal trends in post-graduate course provision in Europe
Christa Janko*, Mike Hardman, Antony Payton, Pavel Dallakian and Michael Wolzt (Vienna, Manchester)

 

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  29.07.2014